IMRT联合TP方案治疗晚期食管鳞癌的临床疗效及对患者血清MMP2、TIMP2、nm23-H1及不良反应的影响  

Effects of IMRT Combined with TP Regimen on Clinical Efficacy,Serum MMP2,TIMP2 and nm23-H1 and Adverse Reactions in Patients with Advanced Esophageal Squamous Cell Carcinoma

作　　者：文恩[1] 秦婷 彭杰[1] WEN En;QIN Ting;PENG Jie(Neijiang First People's Hospital,Neijiang,641000)

机构地区：[1]四川省内江市第一人民医院,641000 [2]四川省内江市东兴区中医医院,641000

出　　处：《实用癌症杂志》2020年第2期311-314,共4页The Practical Journal of Cancer

摘　　要：目的分析调强放射治疗(IMRT)联合TP方案治疗晚期食管鳞癌的临床疗效及对患者血清基质金属蛋白酶2(MMP2)、组织金属蛋白酶抑制剂2(TIMP2)、nm23-H1及不良反应的影响。方法选取晚期食管鳞癌患者80例为研究对象,按随机数字表法将其分为观察组(n=40,采用IMRT联合TP方案化疗)、对照组(n=40,单纯采用IMRT治疗),比较2组临床疗效、治疗前后血清MMP2、TIMP2、nm23-H1表达阳性率、局控率与生存情况及不良反应。结果观察组治疗有效率(85.00%)明显高于对照组(65.00%)(P<0.05)。治疗后2组血清MMP2表达阳性率下降,而TIMP2、nm23-H1表达阳性率上升,且观察组治疗后血清MMP2表达阳性率低于对照组,而TIMP2、nm23-H1表达阳性率高于对照组(P<0.05)。观察组治疗后1年、2年局控率高于对照组,但2组治疗后1年、2年生存率差异无统计学意义(P>0.05)。观察组白细胞减少、放射性食管炎发生率高于对照组(P<0.05),2组其他不良反应发生率差异无统计学意义(P>0.05)。结论晚期食管癌患者采用IMRT联合TP方案治疗可获得较好的疗效,对患者血清MMP2、TIMP2、nm23-H1有明显改善,但可能会较单纯IMRT治疗具有更多不良反应,需加以监测。Objective To analyze the effects of intensity modulated radiation therapy(IMRT)combined with TP regimen on the clinical efficacy,serum matrix metalloproteinase 2(MMP2),tissue inhibitor of metalloproteinase 2(TIMP2),nm23-H1 and adverse reactions in patients with advanced esophageal squamous cell carcinoma.Methods 80 cases of patients with advanced esophageal squamous cell carcinoma who were treated were selected for the study and divided into the observation group(n=40,IMRT combined with TP regimen chemotherapy)and the control group(n=40,IMRT alone)according to random number table method.The clinical efficacy,the expression positive rates of serum MMP2,TIMP2 and nm23-H1,local control rate,survival and adverse reactions before and after treatment were compared between the 2 groups.Results The effective rate of treatment in the observation group was significantly higher than that of the control group(85.00%vs 65.00%)(P<0.05).After treatment,the expression positive rate of MMP2 in the 2 groups was decreased while the expression positive rates of TIMP2 and nm23-H1 were increased,and the expression positive rate of serum MMP2 after treatment in the observation group was lower than that of the control group while the expression positive rate of TIMP2 and nm23-H1 were higher than those of the control group(P<0.05).The local control rate at 1 year and 2 years after treatment in the observation group was higher than that of the control group,and there was no significant difference in the survival rate at 1 year and 2 years after treatment between the 2 groups(P>0.05).The incidence rates of leukopenia and radiation esophagitis in the observation group were higher than those of the control group(P<0.05),and there was no statistically significant difference in the incidence rates of other adverse reactions between the 2 groups(P>0.05).Conclusion IMRT combined with TP regimen is effective for patients with advanced esophageal squamous cell carcinoma,and it can significantly improve the serum MMP2,TIMP2 and nm23-H1,but it may h

关 键 词：IMRT TP方案 晚期 食管鳞癌 临床疗效 MMP2 TIMP2 NM23-H1 不良反应 

分 类 号：R735.1[医药卫生—肿瘤]