ACE2的表达和结肠癌患者生存期的相关性分析  

Correlation analysis between expression of ACE2 and survival of colon cancer patients

作　　者：吴国芳 王倩[2] 费雪洁[2] 陆军 Wu Guofang;Wang Qian;Fei Xuejie;Lu Jun(Department of Medical,Shanghai Fangta Chinese Medicine Hospital,Shanghai 201600,China;Department of Emergency,Shuguang Hospital Affiliated with Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海市松江区方塔中医医院内科,201600 [2]上海中医药大学附属曙光医院急诊科,201203

出　　处：《中华结直肠疾病电子杂志》2020年第1期51-54,共4页Chinese Journal of Colorectal Diseases(Electronic Edition)

基　　金：国家自然科学基金青年项目(No.81801047)

摘　　要：目的探讨ACE2在结肠癌患者中的表达并分析其与结肠癌患者生存期的相关性。方法应用TCGA数据库对结直肠癌患者进行数据分析,通过生物信息学分析,阐明ACE2的表达和结肠癌患者生存期的相关性。结果 ACE2在结肠癌组织中呈高表达(t=0.034,P<0.05),ACE2低表达的结肠癌患者与ACE2高表达的结肠癌患者相比,其生存期延长。结论 ACE2的表达和结肠癌患者生存期的相关。Objective To investigate the expression of ACE2 in colon cancer patients and to analyze its correlation with the survival of colon cancer patients.Methods The TCGA database was used to analyze the colorectal cancer patients.The bioinformatics analysis was used to elucidate the correlation between the expression of ACE2 and the survival of colon cancer patients.Results ACE2 was highly expressed in colon cancer tissues(t=0.034,P<0.05),and colon cancer patients with low expression of ACE2 had longer survival than these with high expression of ACE2.Conclusion The expression of ACE2 is associated with survival in patients with colon cancer.

关 键 词：结肠肿瘤 肿瘤 血管紧张素转化酶2(ACE2) 预后 

分 类 号：R735.35[医药卫生—肿瘤]