基于钕铁硼磁磁压榨技术在肠道吻合中的动物实验研究  

Animal experimental study of neodymium-iron-boron magnetic pressing technique in intestinal anastomosis

作　　者：杨树建 吴荣谦 郑学风[1] 马锋 刘世松 乔玮 史爱华[2,3] 胡继霖 高源[1] 卢强[2,3,4] 吕毅 卢云[1,5] Yang Shujian;Wu Rongqian;Zheng Xuefeng;Ma Feng;Liu Shisong;Qiao Wei;Shi Aihua;Hu Jilin;Gao Yuan;Lu Qiang;Lyu Yi;Lu Yun(Gastrointestinal Surgery,Affiliated Hospital of Qingdao University,Qingdao 266000,China;Local Joint Engineering Research Center for Precision Surgery&Regenerative Medicine,Xi′an 710061,China;Shanxi Province Center for Regenerative Medicine and Surgery Engineering Research,Xi′an 710061,China;Department of Hepatobiliary Surgery,the First Affiliated Hospital of Xi′an Jiaotong University,Xi′an 710061,China;Key Laboratory of Digital Medicine and Computer-assisted Surgery,Affiliated Hospital of Qingdao University,Shandong Province,266003 Qingdao,China)

机构地区：[1]青岛大学附属医院胃肠外科,266000 [2]精准外科与再生医学国家地方联合工程研究中心,西安市710061 [3]陕西省再生医学与外科工程研究中心,西安市710061 [4]西安交通大学第一附属医院肝胆外科,710061 [5]山东省青岛大学附属医院数字医学与计算机辅助手术重点实验室,青岛市266003

出　　处：《中华结直肠疾病电子杂志》2020年第1期55-60,共6页Chinese Journal of Colorectal Diseases(Electronic Edition)

基　　金：教育部创新团队发展计划项目(No.IRT_16R57);陕西省科技资源开放共享平台项目(No.S2016TFPT0024)

摘　　要：目的通过建立家兔结肠的磁压榨吻合模型,验证磁压榨吻合技术在结肠压榨吻合的可行性,并评估压榨吻合口的粪便转流功能。方法选取8只家兔,在结肠置入一定规格的磁铁实现肠道的侧侧压榨吻合,吻合口形成后,通过结肠造影、解剖观察及病理检查的方法评估吻合口的形成情况。人为结扎吻合口之间的肠道制造肠梗阻动物模型,评估压榨吻合口的粪便转流功能。结果8只家兔均在术后第6~8天磁铁脱出;1只家兔发生肠梗阻,其余7只家兔吻合口形成良好。吻合口形成后,取3只家兔结扎吻合口之间肠道,1只家兔于术后第6天死亡,其余2只家兔长期存活,实现了压榨吻合口的粪便转流功能。结论磁压榨吻合技术能够实现家兔肠道的吻合,是一种有效的手术方式。Objective To verify the feasibility of magnetic press anastomosis in colonic press anastomosis by establishing a magnetic press anastomosis model of rabbit colon,and to evaluate the fecal bypass function of the press anastomosis.Methods Eight rabbits were selected and placed on the lateral side of the colon with a certain size of magnet.After the anastomosis was formed,the formation of the anastomosis was evaluated by colonography,anatomical observation and pathological examination.An animal model of intestinal obstruction was made by artificially ligating the intestine between the anastomosis to evaluate the fecal bypass function of the press anastomosis.Results Eight rabbits were exposed to magnets on days 6~8 after operation,and one rabbit developed intestinal obstruction.The other seven rabbits had good anastomosis.The intestinal tract between anastomotic stomas was ligated in 3 rabbits after anastomotic stoma formation,one rabbit died on the 6th day after surgery,and the other 2 rabbits survived for a long time,achieving the fecal bypass function of the press anastomosis.Conclusion The technique of magnetic pressing anastomosis can achieve intestinal anastomosis in rabbits,so it is an effective surgical method.

关 键 词：结肠 胃肠吻合术 磁吻合术 磁压榨 消化道重建 动物模型 

分 类 号：R735.3[医药卫生—肿瘤] R-332[医药卫生—临床医学]