皮肤黑色素瘤中PITX1表达及其与临床病理特征和预后的关系  

Expression of PITX1 in Cutaneous Malignant Melanoma and Its Relationship with Clinicopathological Parameters and Prognosis

作　　者：赵滨 阴亚坤[2] Zhao Bin;Yin Yakun(Third People's Hospital of Henan Province,Zhengzhou 450000,China;First Affiliated Hospital of Zhengzhou University,Zhengzhou 450000,China)

机构地区：[1]河南省直第三人民医院,河南郑州450000 [2]郑州大学第一附属医院,河南郑州450000

出　　处：《中国中西医结合皮肤性病学杂志》2020年第1期20-24,共5页Chinese Journal of Dermatovenereology of Integrated Traditional and Western Medicine

摘　　要：目的研究垂体同源框1(PITX1)表达与皮肤黑色素瘤(CMM)临床病理参数的关系,并探讨PITX1表达与CMM预后之间关系。方法2012年1月2014年2月在本院诊治的CMM患者43例为研究对象,选取同期在本院进行整形手术的皮肤正常者37例为对照。采用免疫组化法检测不同皮肤组织PITX1表达水平,分析PITX1表达与CMM临床病理参数及预后之间的关系。结果PITX1在CMM组织中阳性表达率与良性皮肤增生组织比较明显较低,差异有统计学意义(P<0.05)。PITX1相对表达水平与患者肿瘤溃疡情况、坏死情况、Breslow厚度、Clark分级、肿瘤发展进程(TNM)分期、淋巴结转移等有关,差异均有统计学意义(P<0.05)。Kaplan-Meier生存曲线分析表明,PITX1阳性表达者3年存活率显著高于PITX1表达阴性者(90.91%vs.46.88%,P<0.05)。COX分析结果表明,PITX1、TNM分期是影响CMM患者预后的独立危险因素(HR=2.157,95%CI为1.168~3.983,P<0.05;HR=2.097,95%CI为1.073~4.098,P<0.05)。结论PITX1在CMM组织低表达,是影响CMM患者预后的独立危险因素。Objective In order to investigate the relationship between the expression of pituitary homeobox 1(PITX1)and clinicopathological parameters of cutaneous malignant melanoma(CMM),and to explore the relationship between PITX1 expression and prognosis of cutaneous melanoma.Methods Selected forty-three cases of cutaneous malignant melanoma patients treated in our hospital from January 2012 to February 2014 as the subjects,and 37 cases of normal skin with plastic surgery at the same time in our hospital were selected as controls.The expression levels of PITX1 in different skin tissues were detected by immunohistochemistry,the relationship between the expression of PITX1 and the clinicopathological parameters and prognosis of cutaneous malignant melanoma was analyzed.Results The positive expression rate of PITX1 in the cutaneous malignant melanoma tissues was significantly lower than that in the benign skin hyperplasia tissues,and the differences were statistically significant(P<0.05).The relative expression level of PITX1 was correlated with tumor ulceration,necrosis,Breslow thickness,Clark grading,TNM stage and lymph node metastasis(P<0.05),the differences were statistically significant(P<0.05).The analysis of Kaplan-Meier survival curve showed that the three year survival rate of PITX1-positive patients was significantly higher than that of PITX1-negative patients(90.91%vs.46.88%,P<0.05).COX analysis results showed that PITX1 and TNM staging were independent risk factors for the prognosis of patients with cutaneous malignant melanoma(HR=2.157,95%CI 1.168~3.983,P<0.05,HR=2.097,95%CI 1.073~4.098,P<0.05).Conclusion The low expression of PITX1 in the cutaneous malignant melanoma tissue is an independent risk factor for the prognosis of cutaneous malignant melanoma patients.

关 键 词：皮肤黑色素瘤 垂体同源框1 表达 临床病理特征 预后 

分 类 号：R739.5[医药卫生—肿瘤]