动态对比增强MRI直方图分析在预测食管鳞癌病理分级中的价值  

The value of DCE-MRI histogram analysis in predicting the pathological grades of esophageal squamous cell carcinoma

作　　者：徐露露[1] 王建伟[1] 葛小林 甄福喜[3] 孙娜娜[1] XU Lulu;WANG Jianwei;GE Xiaolin;ZHEN Fuxi;SUN Nana(Deparment of Radiology;Deparment of Radiation Oncology;Department of Thoracic Surgery,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学第一附属医院放射科,江苏南京210029 [2]南京医科大学第一附属医院放射治疗科,江苏南京210029 [3]南京医科大学第一附属医院胸外科,江苏南京210029

出　　处：《实用放射学杂志》2020年第1期42-45,共4页Journal of Practical Radiology

摘　　要：目的研究DCE-MRI定量参数直方图分析在预测食管鳞癌病理分级中的应用价值.方法回顾性分析术前行DCE-MRI检查的食管鳞癌患者59例,入组患者32例.依据术后病理分级分为低级别组(G1~G2,16例)及高级别组(G3,16例).基于整个肿瘤体积的DCE-MRI直方图参数包括容积转移常数(K^trans)、速率常数(Kep)、血管外细胞外容积分数(Ve)、血浆容积分数(Vp)均值及其百分位数值(10th、25th、50th、75th和90th).对2组数据进行独立样本t检验或Mann-Whitney U检验;对有统计学意义的参数行ROC曲线分析来确定诊断效能,并计算其AUC.结果高级别组中K^trans平均值、K^trans 75、K^trans 90、Vp90均高于低级别组(P<0.05),AUC分别为0.711、0.711、0.852及0.723.K^trans 90敏感度为81.25%、特异度为75.00%.结论基于整个肿瘤体积的DCE-MRI直方图分析参数K^trans 90比K^trans平均值在食管鳞癌病理分级中有更高的诊断效能,在预测食管鳞癌病理分级中有一定的临床价值.Objective To evaluate quantitatively and predict the pathological grades of esophageal squamous cell carcinoma using DCE-MRI histogram analysis.Methods Preoperative DCE-MRI data of 59 patients with esophageal squamous cell careinoma were analyzed retrospectively and 32 patients were recruited in this study.Accroding to postoperative pathology,the patients were divided into two groups:low grade group(G1-G2,n=16)and high-grade group(G3,n=16).Histogram parameters based on the entire tumor volume of K^trans,Kep,Vp and Vp included mean,10^th,25^th,50^th,75^th and 90^th percentile values.Independent sample's t-test or Mann Whitney U test was used to compare the parameters between the two groups.ROC were used to determine the diagnostie value.of each significant parameter and AUC were calculated.Results The values of K^trans mean,K^trans75,K^trans90,and Vp90 in the high-grade group were higher than those in the low-grade group(P<0.05).The AUC were 0.711,0.711,0.852 and 0.723,respectively.The K^trans 90's sensitivity and specificity were 81.25%and 75.00%,respectively.Conclusion K^trans to 90,derived from DCE MRI histogram analysis based on the whole tumor,is much powerful than Kinms mean in differentiating and valuable in predicting pathological grades of esophageal squamous cell carcinoma.

关 键 词：食管鳞癌 动态对比增强磁共振成像 直方图分析 病理分级 

分 类 号：R735.1[医药卫生—肿瘤]