联用SLED和HP与联用CRRT和HP治疗重症急性胰腺炎的效果对比  

Comparison of the effects of SLED and HP combined with CRRT and HP in the treatment of severe acute pancreatitis

作　　者：覃冬林[1] 蓝婧[1] 姚朝光[1] 黄霜湘 覃家凭 Qin donglin;Lan jing;yao chaoguang;huang shuangxiang;qin jiaping(department of gastroenterology,guangxi hechi people’s hospital,hechi Guangxi 547000)

机构地区：[1]广西河池市人民医院消化内科

出　　处：《当代医药论丛》2019年第23期85-86,共2页

摘　　要：目的:比较联用连续性肾脏替代(CRRT)治疗和血液灌流(HP)与持续缓慢低效血液透析联用(SLED)和HP治疗重症急性胰腺炎的效果。方法:将广西河池市人民医院收治的76例重症急性胰腺炎患者随机平均分为参照组和观察组。对参照组患者联用CRRT和HP进行治疗。对观察组患者联用SLED和HP进行治疗。然后,比较两组患者血清肿瘤坏死因子(TNF-α)的水平、血清C反应蛋白(CRP)的水平、血清白细胞介素-6(IL-6)的水平、血浆降钙素原(PCT)的水平、床旁平均动脉压(MAP)、心率(HR)、动脉血氧分压/吸入氧气的浓度(Pa02/FiO2)、中心静脉压(CVP)、急性生理与慢性健康(APACHE-Ⅱ)评分、多器官功能障碍征(MODS)评分、全身炎症反应综合征(SIRS)评分、住院的时间、住院的费用及进行血液净化的费用。结果:接受治疗前后,两组患者血清TNF-α的水平、血清CRP的水平、血清IL-6的水平、血浆PCT的水平、MAP、HR、Pa02/FiO2、CVP、APACHE-Ⅱ评分、MODS评分及SIRS评分相比,P>0.05。观察组患者住院的时间短于参照组患者,其住院的费用及进行血液净化的费用均低于参照组患者,P<0.05。结论:与联用CRRT和HP相比,对重症急性胰腺炎患者联用SLED和HP进行治疗可缩短其住院的时间,减轻其经济负担。objective:to compare the efficacy of continuous renal replacement(CRRT)combined with hemoperfusion(HP)combined with continuous slow and inefficient hemodialysis(SLED)combined with HP in the treatment of severe acute pancreatitis.Methods:76 patients with severe acute pancreatitis admitted to the people’s hospital of hechi city,guangxi were randomly divided into the control group and the observation group.Patients in the control group were treated with a combination of CRRT and HP.Patients in the observation group were treated with a combination of SLED and HP.And then,Compare two groups of patients with serum tumor necrosis factor(TNF alpha)level,the level of serum c-reactive protein(CRP)and serum interleukin 6(IL-6)levels,and plasma calcitonin original(PCT)level,beside the bed and mean arterial pressure(MAP),heart rate(HR),arterial blood oxygen partial pressure/oxygen concentration(Pa02/FiO2),central venous pressure(CVP),acute physiology and chronic health(APACHE-Ⅱ)score),multiple organ dysfunction(MODS)score,systemic inflammatory response syndrome(SIRS)score,hospitalization time,hospitalization expenses And the cost of blood purification.Results:before and after treatment,two groups of patients the levels of serum TNF alpha,the levels of serum CRP,the levels of serum IL-6,the levels of plasma PCT,MAP,HR,Pa02/FiO2,CVP,APACHE-Ⅱscore,SIRS and MODS score score than,P>0.05.The duration of hospitalization in the observation group was shorter than that in the control group,and the cost of hospitalization and blood purification was lower than that in the control group,P<0.05.Conclusion:compared with CRRT and HP,SLED combined with HP in patients with severe acute pancreatitis can shorten their hospitalization time and reduce their economic burden.

关 键 词：血液透析模式 连续性肾脏替代治疗 重症急性胰腺炎 持续缓慢低效血液透析 

分 类 号：R576[医药卫生—消化系统]