复方海藻琼脂对糖尿病大鼠降血糖作用研究  

Hypoglycemic Effect of Compound Seaweed Agar on Diabetic Rats

作　　者：郑林静 叶静[1,2] 黄雅燕[1,2] 张娜[1,2] 肖美添 ZHENG Lin-jing;YE Jing;HUANG Ya-yan;ZHANG Na;XIAO Mei-tian(College of Chemical Engineering,Huaqiao Univer sity,Quanzhou 362021,China;Engineering Technology Research Center for Comp rehensive Utilization of Marine Biological Resources in Xiamen,Huaqiao Universi ty,Xiamen 361021,China)

机构地区：[1]华侨大学化工学院,福建泉州362021 [2]华侨大学厦门市海洋生物资源综合利用工程技术研究中心,福建厦门361021

出　　处：《海峡药学》2019年第12期17-21,共5页Strait Pharmaceutical Journal

基　　金：海洋公益性行业科研专项经费项目(201305015-2,201505026-5)

摘　　要：目的研究对Ⅱ型糖尿病大鼠的降血糖作用。方法Ⅱ型糖尿病大鼠模型的建立是通过注射四氧嘧啶。大鼠分为正常组、模型对照组、阳性对照二甲双胍给药组(200mg/(kg·d))、复方海藻琼脂给药组(200、400、800mg/(kg·d)),观察复方海藻琼脂对Ⅱ型糖尿病大鼠的降血糖作用,并从体重、空腹血糖、口服葡萄糖耐量、摄食量、动物血清中TG、TC、HDL-c、LDL-c、SOD、GSH-Px、MDA的含量等方面考察复方海藻琼脂对Ⅱ型糖尿病大鼠糖代谢的改善作用。结果在给药4周后,可明显改善大鼠体重下降症状和葡萄糖耐量,降低空腹血糖水平,升高血清中的HDL-c,降低TC、TG和LDL-c水平,提高SOD和GSH-Px的活性,降低肝脏MDA含量。结论复方海藻琼脂能有效降低糖尿病大鼠模型的血糖水平,并对肝脏有一定的保护作用。OBJECTIVE To study the hypoglycemic effect of compound seaweed agar on type 2 diabetic rats.METHODS The model of type 2 diabetic rats was established by injecting alloxan.Rats were divided into normal group,model group,metformin positive control group(200 mg/(kg·d))and compound seaweed agar group(200,400,800 mg/(kg·d)).The effects of compound seaweed agar on glucose metabolism in type 2 diabetic rats were investigated from the aspects of body weight,food intake,fasting blood glucose,oral glucose tolerance and the content of TG,TC,HDL-c,LDL-c,SOD,GSH-Px,MDA in animal serum.RESULTS After four weeks of administration,the symptoms of weight loss and glucose tolerance were significantly improved,fasting blood glucose level was decreased,serum HDL-c was increased,TC,TG and LDL-c levels were decreased,and the activities of SOD and GSH-Px were increased.The content of MDA in liver was decreased.CONCLUSION Compound seaweed agar can effectively reduce the blood glucose level of diabetic rat model and has certain protective effect on liver.

关 键 词：海藻琼脂 中药提取物 Ⅱ型糖尿病 降血糖 

分 类 号：R965[医药卫生—药理学]