463例鼻腔鼻窦恶性肿瘤病理组织分型的疾病谱分析  

Spectrum analysis of pathological classification in 463 cases with nasal and paranasal sinuses malignant tumors

作　　者：李佳[1,2] 袁虎 李云[2] 赵兴泉[2] 陈雷[1] 韩明鲲[1] 刘宸箐[1] 刘穹[1] 王洪田[1] 钟渠[2] 冯勃[1] LI Jia;YUAN Hu;Li Yun;ZHAO Xinaquan;CHEN Lei;HAN Mingqkun;LIU Chenqing;LIU Qiong;WANG Hongtian;ZHONG Qu;FENG Bo(Department of Otorhinolaryngology Head and Neck Surgery,Hospital 301,PLA General Hospital,Beijing,100853,China;Department of Otorhinolaryngology Head and Neck Surgery,the Second Affiliated Hospital of North Sichuan Medical College,Sichuan Mianyang 404 Hospital)

机构地区：[1]解放军总医院耳鼻咽喉头颈外科,国家耳鼻咽喉疾病临床医学研究中心,聋病教育部重点实验室,聋病防治北京市重点实验室,北京100853 [2]川北医学院附属第二医院四川绵阳四〇四医院耳鼻咽喉头颈外科

出　　处：《临床耳鼻咽喉头颈外科杂志》2019年第12期1176-1180,共5页Journal of Clinical Otorhinolaryngology Head And Neck Surgery

基　　金：国家863计划(No:2015AA8092017D);耳鼻咽喉头颈外科住院患者多疾病数据库构建和疾病谱深度分析(No:2017MBD-018)

摘　　要：目的:分析近10年鼻腔鼻窦恶性肿瘤病理组织分型的特征,旨在为临床制定有效的治疗措施提供依据及思路。方法:收集解放军总医院10年间收治的463例鼻腔鼻窦恶性肿瘤患者的临床资料,分析病理类型,并计算该类患者的疾病谱分布、构成比和变化趋势。结果:总体位于前五的病理类型分别为鳞状细胞癌,腺样囊性癌,嗅神经母细胞瘤,黑色素瘤和腺癌。男性位于前五的病理类型分别为鳞状细胞癌,腺样囊性癌,嗅神经母细胞瘤,腺癌,神经内分泌癌与横纹肌肉瘤并列第五;女性位于前五的病理类型分别为鳞状细胞癌,腺样囊性癌,黑色素瘤,横纹肌肉瘤,腺癌。2009-2013年的5年间鼻腔鼻窦恶性肿瘤患者共183例,位列前五的病理类型分别为鳞状细胞癌,腺样囊性癌,嗅神经母细胞瘤,黑色素瘤,神经内分泌癌与横纹肌肉瘤并列第五;2014-2018年的5年间鼻腔鼻窦恶性肿瘤患者280例,位列前五的病理类型分别为鳞状细胞癌,腺样囊性癌,黑色素瘤,腺癌,横纹肌肉瘤;前后2个5年间患者数量比值约为0.65∶1。鼻腔鼻窦恶性肿瘤好发于41~60岁,且前五位的病理类型分别为鳞状细胞癌,腺样囊性癌,腺癌,黑色素瘤和神经内分泌癌。结论:鼻腔鼻窦恶性肿瘤好发于男性,且以鳞状细胞癌、腺样囊性癌、嗅神经母细胞瘤等病理类型高发;各个年龄段均有发病,以41~60岁年龄段为高危人群。近5年来,黑色素瘤的患病率逐渐增加,需予以重视。Objective:The characteristics of pathological histological classification of nasal and paranasal sinuses malignant tumors in the past 10 years were analyzed,so as to provide possible basis,direction and ideas for the development of relevant effective treatment measures for nasal and paranasal sinuses malignant tumors in clinical practice.Method:The clinical data of patients with nasal and paranasal sinuses malignant tumors admitted to PLA general hospital from January 2009 to December 2018 were collected.Pathological types were retrospectively analyzed,and disease spectrum distribution,composition ratio and variation tendency of these patients were calculated.Result:Among the 463 patients,the overall pathological types in the top 5 were as follows:squamous cell carcinoma,adenoid cystadenocarcinoma,olfactory neuroblastoma,melanoma,adenocarcinoma.As for male patients,the pathological types in the top 5 were squamous cell carcinoma,adenoid cystic carcinoma,olfactory neuroblastoma,adenocarcinoma,neuroendocrine carcinoma and rhabdomyosarcoma were tied for fifth;the top 5 most common pathological types in female patients were squamous cell carcinoma,adenoid cystic carcinoma,melanoma,rhabdomyosarcoma,and adenocarcinoma.From 2009 to 2013,there were 183 patients with nasal and paranasal sinuses malignant tumors,the top 5 pathological types were squamous cell carcinoma,adenoid cystadenocarcinoma,olfactory neuroblastoma,melanoma,neuroendocrine carcinoma and rhabdomyosarcoma were tied for fifth;From 2014 to 2018,280 patients with nasal and paranasal sinuses malignant tumors were diagnosed,the top 5 pathological types were squamous cell carcinoma,adenoid cystadenocarcinoma,melanoma,adenocarcinoma,and rhabdomyosarcoma.The ratio of the number of patients from 2009 to 2013 and 2014 to 2018 was about 0.65∶1.Malignant tumors of the nasal and paranasal sinuses tend to occur between the ages of 41 and 60,and the pathological types in the top 5 were squamous cell carcinoma,adenoid cystic carcinoma,adenocarcinoma,melanoma,neuroendoc

关 键 词：鼻腔 鼻窦肿瘤 病理学 疾病谱 

分 类 号：R739.62[医药卫生—肿瘤]