水相中镍催化微波辅助合成喹唑啉酮衍生物的反应  

Microwave-assisted nickel-catalyzed preparation of quinazolinones in water

作　　者：李震[1] 刘圣亚 李飞 孔迎春 翁维 王斌 LI Zhen;LIU Sheng-ya;LI Fei;KONG Ying-chun;WENG Wei;WANG Bin(College of Chemistry and Chemical Engineering,Yunnan Normal University,Kunming 650500,China;Faculty of Graduate studies,Assumption University,Bangkok 10240,Thailand)

机构地区：[1]云南师范大学化学化工学院,云南昆明650500 [2]FacultyofGraduatestudies,AssumptionUniversity,泰国曼谷10240

出　　处：《化学研究与应用》2020年第2期292-296,共5页Chemical Research and Application

基　　金：国家自然科学基金项目(21777136)资助

摘　　要：建立了一种以氯化镍与脯氨酸锂作为催化剂,在水相中即可简单、高效地以2-卤代苯甲酰胺和脒类盐酸盐合成喹唑啉酮衍生物的方法。该方法具有操作简便,无毒的特点,成本低廉,并且所有底物均能以较高的产率得到喹唑啉酮类衍生物,最高产率达91%。A simple and efficient method for synthesizing quinazolinones from substituted 2-halobenzamides and amidines was developed by nickel proline lithium-catalysis in water as an eco-friendly medium.The present methodology was operationally simple,non-toxic and varieties of quinazolinones were obtained in high yields of up to 91%.

关 键 词：喹唑啉酮 氯化镍 2-卤代苯甲酰胺 脒盐 水相 

分 类 号：O626.2[理学—有机化学]