收缩功能不全性心力衰竭心肌逆向重构:一个尚未解决的难题  

Myocardial reverse remodeling in systolic insufficiency heart failure:a puzzle yet to be solved

作　　者：李海嵘[1] 陈关良[1] 方小丽[1] 蔡兴赳[1] 许荣丽[1] 林慕如[1] LI Hairong;CHEN Guanliang;FANG Xiaoli;CAI Xingjiu;XU Rongli;LIN Muru(Cardiovascular Institute,Hainan Clinical Medicine Research Institution,Department of Cardiology,Hainan Provincial People’s Hospital,Haikou 570311,China)

机构地区：[1]海南省人民医院心血管内科海南省临床医学研究院心血管病研究所

出　　处：《医学争鸣》2020年第1期50-52,共3页Negative

基　　金：国家临床重点专科建设项目(卫办医政函〔2011〕873号)

摘　　要：收缩功能不全性心力衰竭心肌逆向重构的发现是心力衰竭治疗领域取得的最大进展之一,它可能将现有延缓心肌重构过程"消极防御"的治疗模式,转变为加速逆向重构"主动出击"的治疗模式。然而对于逆向重构确切始动因素却知之甚少,这就造成了一些认识上的争议和矛盾,主要有:①心力衰竭逆向重构存在差异性生物学特征;②心力衰竭逆向重构临床评价尚无统一判断标准;③心力衰竭逆向重构有效治疗方案莫衷一是。这些问题有待基础医学研究,甚至是患者临床试验进一步解决。The discovery of myocardial reverse remodeling in patients with systolic dysfunctional heart failure is one of the greatest advances in the field of heart failure treatment.It may transform the existing treatment mode of“negative defense”that delays myocardial remodeling into accelerated reverse remodeling.However,little is known about the exact starting factors of reverse remodeling,which has caused some controversies and contradictions in understanding.There are mainly:①There are different biological characteristics in the reverse remodeling of heart failure;②There is no unified judgment standard for clinical evaluation in reverse remodeling of heart failure;③The effective treatment plan for reverse remodeling of heart failure is inconsistent.Further basic medical research,and even further clinical trials of patients are needed to solve the problem.

关 键 词：逆向重构 收缩功能不全性心力衰竭 生物学特征 临床评价 

分 类 号：R-0[医药卫生]