多粘菌素B相关皮肤色素沉着的研究进展  

Research progress of polymyxin B-associated skin hyperpigmentation

作　　者：张少楠[2] 黄晓晖 岳慧杰 Zhang Shaonan;Huang xiaohui;Yue Huijie(Department of Pharmacology,General Hospital of Eastern Theater Command,Nanjing 21002,China;Department of Pharmacy,the Second People's Hospital of Wuhu,Anhui Province,Wuhu 241000,China)

机构地区：[1]东部战区总医院药理科,南京210002 [2]安徽省芜湖市第二人民医院药剂科,241000

出　　处：《药物不良反应杂志》2020年第1期38-41,共4页Adverse Drug Reactions Journal

摘　　要：多粘菌素B主要用于治疗严重耐药革兰阴性菌感染,近年来关于该药致皮肤色素沉着的报道逐渐增多。婴儿多粘菌素B相关皮肤色素沉着发生率高于成人。多粘菌素导致色素沉着的机制尚不明确,很可能与多粘菌素B可诱导组胺释放、诱导皮肤炎症反应、促进黑色素生成增多有关。皮肤色素沉着虽然对患者的治疗和预后无明显影响,但可能给患者心理造成负担,影响患者的生活质量,应引起临床关注和进一步研究。Polymyxin B is mainly used in the treatment of severe drug-resistant gram-negative bacterial infection.In recent years,more and more cases of skin pigmentation caused by polymyxin B have been reported.The incidence of polymyxin B-related skin pigmentation in infants was higher than that in adults.The mechanism of polymyxin B-induced hyperpigmentation is not clear,which may be related to histamine release,skin inflammation,and the stimulation of melanin synthesis induced by polymyxin B.Although skin pigmentation has no significant effect on the treatment and prognosis in patients,it may cause psychological burden and affect the life quality,which should be paid more attention to and further studied.

关 键 词：多粘菌素B 皮肤色素沉着 色素沉着过多 

分 类 号：TS2[轻工技术与工程—食品科学与工程]