铝镁二甲硅油咀嚼片联合艾司奥美拉唑治疗消化性溃疡合并出血的疗效及安全性分析  

Efficacy and safety analysis of alumina, magnesia and dimethicone chawable tablets combined with esmeralazole in the treatment of peptic ulcer with hemorrhage

作　　者：陈伟平 陈钦明 蔡娉娉 CHEN Wei-ping;CHEN Qin-ming;CAI Ping-ping(Digestive System Department,Puning People’s Hospital,Puning 515300,China)

机构地区：[1]普宁市人民医院消化内科

出　　处：《中国现代药物应用》2020年第3期7-10,共4页Chinese Journal of Modern Drug Application

摘　　要：目的研究铝镁二甲硅油咀嚼片联合艾司奥美拉唑治疗消化性溃疡合并出血的效果。方法200例消化性溃疡合并出血患者,按照随机数字表法分为对照组和观察组,每组100例。对照组患者接受艾司奥美拉唑治疗,观察组患者接受铝镁二甲硅油咀嚼片联合艾司奥美拉唑治疗。比较两组患者治疗前后症状积分;治疗后止血情况(止血时间、输血量、治疗后1个月内再出血)、住院时间;治疗前后超氧化物歧化酶(SOD)水平;治疗后不良反应发生情况;治疗前后生活质量评分。结果治疗前,两组患者的症状积分比较差异无统计学意义(P>0.05);治疗2、4周后,两组患者的症状积分均低于本组治疗前,且观察组明显低于对照组,差异均具有统计学意义(P<0.05)。观察组患者的治疗后止血时间(6.85±2.61)d、住院时间(12.38±3.65)d均短于对照组的(10.94±2.72)、(15.94±4.18)d,输血量(2.46±1.16)U少于对照组的(3.84±1.42)U,治疗后1个月内再出血率3.00%低于对照组的10.00%,差异均具有统计学意义(P<0.05)。治疗前,两组患者的SOD水平比较差异无统计学意义(P>0.05);治疗后,两组患者的SOD水平均高于本组治疗前,且观察组SOD水平明显高于对照组,差异均具有统计学意义(P<0.05)。观察组患者治疗后不良反应发生率为13.00%,与对照组的11.00%比较差异无统计学意义(P>0.05)。治疗前,两组患者的生活质量评分比较,差异无统计学意义(P>0.05);治疗后,观察组患者的生活质量评分明显高于对照组,差异具有统计学意义(P<0.05)。结论铝镁二甲硅油咀嚼片联合艾司奥美拉唑治疗消化性溃疡合并出血对比单独应用艾司奥美拉唑方案能获得更好的临床疗效,明显改善症状,有效控制血清指标水平,且治疗安全性较高,值得推广应用。Objective To study the effect of alumina,magnesia and dimethicone chawable tablets combined with esmeralazole in the treatment of peptic ulcer with hemorrhage.Methods A total of 200 cases of peptic ulcer with hemorrhage were divided into control group and observation group by random number table method,with 100 cases in each group.The control group was treated by esmeralazole,and the observation group was treated by alumina,magnesia and dimethicone chawable tablets combined with esmeralazole.The symptom integral before and after treatment;hemostasis condition(hemostasis time,amount of blood transfusion and rehemorrhage within 1 month after treatment)after treatment,hospitalization time;superoxide dismutase(SOD)level before and after treatment;occurrence of adverse reactions after treatment;quality of life score before and after treatment were compared between the two groups.Results Before treatment,there was no statistically significant difference in symptom integral between the two groups(P>0.05).After 2 and 4 weeks of treatment,the symptom integral in the two groups was lower than those before treatment,and the observation group was obviously lower than those in the control group.Their difference was statistically significant(P<0.05).After treatment,hemostasis time(6.85±2.61)d and hospitalization time(12.38±3.65)d in the observation group were shorter than(10.94±2.72)and(15.94±4.18)d in the control group,amount of blood transfusion(2.46±1.16)U was less than(3.84±1.42)U in the controlgroup,and rehemorrhage within 1 month after treatment 3.00%was lower than 10.00%in the control group.Their difference was statistically significant(P<0.05).Before treatment,there was no statistically significant difference in the level of SOD between the two groups(P>0.05).After treatment,the level of SOD in the two groups was higher than that before treatment,and the level of SOD in the observation group was obviously higher than that before treatment.Their difference was statistically significant(P<0.05).After treatment,the

关 键 词：铝镁二甲硅油咀嚼片 艾司奥美拉唑 消化性溃疡 出血 安全性 

分 类 号：R573.1[医药卫生—消化系统]