糖原合成酶激酶3β、糖蛋白-1、β-连环蛋白在近端胃癌组织中的表达及意义  

Expression and clinical value of glycogen synthase kinase-3β,Dickkopf-1 andβ-catenin in proximal gastric cancer

作　　者：胡巍巍 侯英楠 Hu Weiwei;Hou Yingnan(Department of Clinical Laboratory,Chengfeng Hospital of Daqing Oilfield Group,Daqing,Heilongjiang 163411,China)

机构地区：[1]大庆油田乘风医院检验科,黑龙江省163411

出　　处：《中国基层医药》2020年第1期68-72,共5页Chinese Journal of Primary Medicine and Pharmacy

摘　　要：目的探讨糖原合成酶激酶3β(GSK-3β)、糖蛋白-1(DKK-1)、β-连环蛋白(β-catenin)在近端胃癌组织中的表达及临床意义。方法选择大庆油田总医院集团乘风医院2016年4月至2017年4月确诊的近端胃癌患者47例为研究对象,对患者病灶组织、癌旁组织及正常组织进行免疫组织化学检测,对比不同因素对GSK-3β、DKK-1、β-catenin表达的影响。结果正常组织中GSK-3β阳性表达率为70.21%(33/47),高于病灶组织、癌旁组织的21.28%(10/47)、21.28%(10/47)(χ2=31.985,P<0.01);胃癌组织DKK-1、β-catenin阳性表达率分别为38.30%(18/47)、82.98%(39/47),均高于癌旁组织的8.51%(4/47)、8.51%(4/47)和正常组织的6.38%(3/47)、2.13%(1/47)(χ2=20.517、88.471,均P<0.01)。原发灶淋巴结远处转移(TNM)分期Ⅰ~Ⅱ期、中高分化、浸润≥50%、淋巴未转移者GSK-3β阳性表达率高(P<0.05);TNM分期Ⅲ~Ⅳ期、中高分化、浸润不足50%者DKK-1阳性表达率高(P<0.05)。结论GSK-3β、DKK-1、β-catenin表达在胃癌患者病情发展、转移中有重要作用,在临床诊断、疗效评估方面有一定价值。Objective To study the expression and clinical value of glycogen synthase kinase-3β(GSK-3β),Dickkopf-1(DKK-1)and β-catenin in patients with proximal gastric cancer.Methods From April 2016 to April 2017,47 patients with proximal gastric cancer in Chengfeng Hospital of Daqing Oilfield Group were enrolled in this study.Immunohistological tests were performed in all patients'lesions,adjacent tissues and healthy tissues.The effects of different factors on the expression of GSK-3βand DKK-1 were compared.Results The positive expression rate of GSK-3βin the normal tissues of patients with proximal gastric cancer was 70.21%(33/47),which was higher than those in the lesions and adjacent tissues[21.28%(10/47),21.28%(10/47)](χ2=31.985,P<0.01).The positive expression rates of DKK-1 andβ-catenin in the gastric cancer tissues were 38.30%(18/47),82.98%(39/47),respectively,which were higher than those in the adjacent tissues and normal tissues[8.51%(4/47),8.51%(4/47),and 6.38%(3/47),2.13%(1/47)](χ2=20.517,88.471,all P<0.01).The GSK-3βpositive expression rate was higher in patients with tumor node metastasis(TNM)stage Ⅰ-Ⅱ,moderately well differentiated,infiltrated more than 50%,non-metastatic lymph nodes(P<0.05).The DKK-1 positive expression rate was higher in patients with TNM stage Ⅲ-Ⅳ,moderately well differentiated and less than 50%infiltrated lymph nodes(P<0.05).Conclusion GSK-3β,DKK-1 andβ-catenin are important indicators in the development and metastasis of gastric cancer.The above indicators have clinical value in the diagnosis and evaluation of curative effect.

关 键 词：胃肿瘤 糖原合成酶激酶3 糖蛋白类 纤连蛋白类 基因表达调控 肿瘤 肿瘤转移 细胞分化 淋巴细胞 肿瘤浸润 

分 类 号：R735[医药卫生—肿瘤]