为复发性上皮性卵巢癌患者选择不同的时机及方案进行治疗对其生存率的影响  

The effect of different timing and treatment regimens on survival of patients with recurrent epithelial ovarian cancer

作　　者：王群 Wang Qun(department of gynecology,xindu district hospital of traditional Chinese medicine,Chengdu Sichuan)

机构地区：[1]成都市新都区中医医院妇科

出　　处：《当代医药论丛》2020年第2期8-10,共3页

摘　　要：目的:探讨为复发性上皮性卵巢癌患者选择不同的时机及方案进行治疗对其生存率的影响,并分析可影响该病患者生存率的相关因素。方法:回顾性分析成都市新都区中医医院收治的76例复发性上皮性卵巢癌患者的临床资料。比较这些患者中选择不同的时机及方案进行治疗的患者生存率的差异,分析可影响复发性上皮性卵巢癌患者生存率的相关因素。结果:在出现临床症状后开始接受治疗的患者和在两次血清CA125水平升高时开始接受治疗的患者,其生存率相比,P>0.05。采用手术联合化疗的方式进行治疗患者的生存率高于单纯进行化疗的患者,P<0.01。复发性上皮性卵巢癌患者肿瘤的FIGO分期、进行手术后其残余瘤的大小与其生存率密切相关,P<0.05。复发性上皮性卵巢癌患者的年龄、血清CA125的水平、卵巢癌的组织学分型、癌细胞分化的程度与其生存率无明显的相关性,P>0.05。结论:在出现临床症状后开始接受治疗的复发性上皮性卵巢癌患者与在两次血清CA125水平升高时开始接受治疗的复发性上皮性卵巢癌患者2年生存率相比差异不明显。与单纯进行化疗相比,进行手术联合化疗的该病患者2年生存率较高。肿瘤的FIGO分期、进行手术后残余瘤的大小是影响该病患者生存率的相关因素。Objective:To investigate the influence of different treatment timing and regimens on the survival rate of patients with recurrent epithelial ovarian cancer,and to analyze the relevant factors affecting the survival rate of patients with recurrent epithelial ovarian cancer.Methods:the clinical data of 76 patients with recurrent epithelial ovarian cancer admitted to xindu district hospital of traditional Chinese medicine in chengdu were retrospectively analyzed.The differences in survival rates among these patients with different timing and treatment regimens were compared to analyze the factors affecting survival rates in patients with recurrent epithelial ovarian cancer.Results:compared with patients who started treatment after the onset of clinical symptoms and those who started treatment after two elevated serum CA125 levels,the survival rate was P>0.05.The survival rate of patients treated with surgery combined with chemotherapy was higher than that of patients treated with chemotherapy alone,P<0.01.FIGO staging and residual tumor size after surgery were closely correlated with survival rate in patients with recurrent epithelial ovarian cancer,P<0.05.The age of patients with recurrent epithelial ovarian cancer,the level of serum CA125,the tissue type of ovarian cancer and the degree of differentiation of cancer cells had no significant correlation with the survival rate,P>0.05.Conclusions:there was no significant difference in 2-year survival in patients with recurrent epithelial ovarian cancer who began treatment after the onset of clinical symptoms compared with those who began treatment with two elevated serum CA125 levels.Compared with chemotherapy alone,the 2-year survival rate was higher in patients with the disease who received surgery combined with chemotherapy.The FIGO stage of the tumor and the size of the residual tumor after surgery are the relevant f actors affecting the survival rate of patients with the disease.

关 键 词：治疗时机 治疗方案 复发性上皮性卵巢癌 生存率 相关因素 

分 类 号：R737[医药卫生—肿瘤]