胱抑素C、高敏C反应蛋白、尿酸水平检测对脑小血管病的临床意义  

Clinical Significance of Cystatin C,High-sensitive C reactive protein and Uric Acid in Cerebral Small Vessel Disease

作　　者：吴显川 王远桥 李林敏 邓志[2] WU Xian-chuan;WANG Yuan-qiao;LI Lin-min(Dazhou Hospital of Integrated Traditional Chinese and Western Medicine:Department of Critical Care Medicine,Dazhou,Sichuan 635000)

机构地区：[1]达州市中西医结合医院重症医学科,四川达州635000 [2]达州市中西医结合医院神经内科,四川达州635000

出　　处：《医学临床研究》2019年第12期2349-2351,共3页Journal of Clinical Research

摘　　要：【目的】探讨胱抑素C(Cys-C)、高敏C反应蛋白(hs-CRP)、尿酸(UA)水平检测对脑小血管病(CSVD)的临床意义。【方法】选择2016年8月至2017年8月本科室收治的CSVD患者98例作为研究对象(观察组),选择同期在本院行核磁共振检查脑血管正常者98例为对照组。比较两组患者Cys-C、hs-CRP、UA水平。根据蒙特利尔评估表将CSVD患者分为认知障碍组54例与认知正常组44例,比较两组患者Cys-C、hs-CRP、UA水平,应用Logistic回归分析及Pearson相关分析发生认知功能障碍的危险因素。【结果】观察组患者Cys-C、hs-CRP、UA水平明显高于正对照组,差异具有统计学意义(P<0.05);认知障碍组患者UA水平明显高于认知正常组,差异相比具有统计学意义(P<0.05);尿酸为发生CSVD的独立危险因素,UA水平与MoCA总评分、执行能力、语言、延迟回忆、命名呈负相关。【结论】CSVD患者Cys-C、hs-CRP、UA水平升高,其中尿酸为认知障碍的危险因素,能促进认知功能障碍的发生。【Objective】To investigate the clinical significance of cystatin C(Cys-C),high-sensitive C reactive protein(hs-CRP)and uric acid(UA)in patients with cerebral small vessel disease(CSVD).【Methods】A total of 98 patients with CSVD admitted to our hospital from August 2016 to August 2017 were selected as the observation group,while 98 volunteers with normal cerebrovascular examination in our hospital were selected as the control group.All patients underwent MRI examination.Levels of cystatin C,high-sensitive C reactive protein and uric acid in two groups were compared.The patients with CSVD were further divided into the cognitive impairment group(n=54)and normal cognition group(n=44)and levels of cystatin C,high-sensitive C reactive protein and uric acid between two groups were compared.Risk factors and correlation of cognitive impairment were analyzed by Logistic regression analysis and Pearson correlation analysis.【Results】Levels of cystatin C,high-sensitive C reactive protein and uric acid in the observation group were higher than those in the control group;The differences were statistically significant(P<0.05).The were no significantly differences of the levels of cystatin C and high-sensitive C reactive protein in the groups of cognitive impairment and normal cognition CSVD patients,however,the level of UA in the cognitive impairment group was higher than that in the cognitively normal group(P<0.05).Uric acid was an independent risk factor for the occurrence of CSVD and it was negatively correlated with total score of MoCA,executive ability,language capacity and delayed recall.【Conclusion】The levels of cystatin C,high sensitive C reactive protein and uric acid in the patients with CSVD were elevated.The level of uric acid was a risk factor for cognitive impairment.

关 键 词：大脑小血管疾病/诊断 C反应蛋白质 尿酸 

分 类 号：R742[医药卫生—神经病学与精神病学]