微生态制剂对食管癌术后患者消化道并发症及营养状况临床疗效的随机对照试验  

Clinical effect of microecological preparation on digestive tract complications and nutritional status after esophageal cancer surgery: A randomized controlled study

作　　者：李东航 耿庆[1] 张霖 汪巍[1] 江文洋[1] 卢子龙 冯浩杰 LI Donghang;GENG Qing;ZHANG Lin;WANG Wei;JIANG Wenyang;LU Zilong;FENG Haojie(Department of Thoracic Surgery,Renmin Hosptial of Wuhan University,Wuhan,430060,P.R.China)

机构地区：[1]武汉大学人民医院胸外科

出　　处：《中国胸心血管外科临床杂志》2020年第3期312-317,共6页Chinese Journal of Clinical Thoracic and Cardiovascular Surgery

基　　金：国家自然科学基金面上项目(81770095)

摘　　要：目的分析食管癌术后应用微生态制剂对消化道并发症及营养状况的影响。方法选取2017年10月至2019年6月武汉大学人民医院胸外科收治的146例食管癌术后患者,其中男91例、女55例,年龄65(61.9±8.2)岁。术后1周可进食时按是否给予微生态制剂将患者随机分为两组,观察组(口服微生态制剂)和对照组(常规饮食),每组各73例。对比两组患者术后1个月内出现厌食、反酸、恶心、呕吐、腹泻(≥3次/d)等消化道并发症及营养状况。结果术后1个月内观察组患者较对照组厌食、恶心、腹泻(≥3次/d)、吻合口瘘及吻合口狭窄发生率更低,营养状况指标更高,差异有统计学意义(P均<0.05)。两组患者术后1个月内反酸、呕吐、肺部感染、切口感染的发生率差异无统计学意义(P均>0.05)。结论食管癌术后予以微生态制剂治疗,可调节胃肠道微生态平衡、改善患者术后营养状况、降低消化道并发症发生率、加快患者术后康复进程。Objective To analyze the effect of microecological preparation on digestive tract complications and nutritional status after esophageal cancer surgery.Methods A total of 146 patients with esophageal cancer admitted to the Department of Thoracic Surgery,Renmin Hospital of Wuhan University from October 2017 to June 2019 were selected.There were 91 males and 55 females,aged 65(61.9±8.2)years.They were randomly divided into two groups(an observation group and a control group,n=73 in each group)according to whether microecological preparation was given when they could take food one week after the surgery.Nutritional status and the incidence of gastrointestinal complications including anorexia,acid reflux,nausea,vomiting and diarrhea(≥3 times per day)in the first month after operation were compared between the two groups.Results The incidence of anorexia,nausea,diarrhea(≥3 times per day),anastomotic fistula and stenosis in the observation group was lower and the index of nutritional status was higher than those in the control group within one month after the operation(all P<0.05).There was no statistically significant difference in acid reflux,vomiting,lung infection and incision infection between the two groups(all P>0.05).Conclusion Microecological preparation can regulate gastrointestinal microecological balance,improve nutritional status,reduce the incidence of gastrointestinal complications and accelerate the postoperative rehabilitation.

关 键 词：微生态制剂 食管癌 并发症 营养状况 

分 类 号：R735.1[医药卫生—肿瘤]