吲哚菁绿标记的近红外荧光腹腔镜技术在胃癌手术中的应用  

Application of indocyanine green labeled near-infrared fluorescence laparoscopy in gastric cancer

作　　者：刘茂兴[1] 邢加迪[1] 苏向前[1] Liu Maoxing;Xing Jiadi;Su Xiangqian(Department of Gastrointestinal Surgery IV,Peking University Cancer Hospital&Institute,Key laboratory of Carcinogenesis and Translational Research(Ministry of Education),Beijing 100142,China)

机构地区：[1]北京大学肿瘤医院暨北京市肿瘤防治研究所胃肠肿瘤中心恶性肿瘤发病机制及转化研究教育部重点实验室,100142

出　　处：《中华肿瘤杂志》2019年第12期891-895,共5页Chinese Journal of Oncology

基　　金：国家自然科学基金(81872022、81672439、81272766、81450028);北京市自然科学基金(7162039);首都卫生发展科研专项(首发2018-2-2153);北京市医院管理局临床医学发展专项(XM201309、ZYLX201701)。

摘　　要：随着外科技术和腹腔镜技术的进步,微创外科理念逐渐深入人心,腹腔镜微创技术应用于胃癌根治术已被广大外科医师认可。近年来,吲哚菁绿(ICG)标记的近红外荧光腹腔镜技术逐渐应用于胃癌手术治疗中,此技术克服了腹腔镜下缺少触觉的弊端,使胃癌腹腔镜手术更加精准化、微创化。文章中介绍了ICG的注射方法,并探讨了荧光腹腔镜在胃癌手术操作中的应用效果,主要包括早期胃癌的术中肿瘤定位、前哨淋巴结活检、进展期胃癌的淋巴结导航清扫以及消化道重建过程中胃肠血流灌注评估。Objective With the development of laparoscopic surgery technique,the concept of minimally invasive surgery has gradually gained popularity.Laparoscopic minimally invasive technique applied in the treatment of gastric cancer has been recognized by surgeons.In recent years,the indocyanine green labeled near-infrared fluorescence laparoscopic technique has been gradually applied to the surgical treatment of gastric cancer.This technique overcomes the drawbacks of tactile lack of laparoscopic surgery and makes the laparoscopic surgery of gastric cancer more precise and minimally invasive.This article introduces the injection method of indocyanine green and discusses the application of fluorescent laparoscopy in gastric cancer surgery,including intraoperative tumor localization of early gastric cancer,sentinel lymph node biopsy,lymph node navigation of advanced gastric cancer,digestive tract reconstruction and gastrointestinal blood perfusion assessment during the procedure.

关 键 词：吲哚菁绿 胃肿瘤 荧光显像 腹腔镜 

分 类 号：R735[医药卫生—肿瘤]