对氯甲基苯乙烯的合成工艺研究  

Synthetic Process of p-Chloromethyl Styrene

作　　者：程超[1,2,3] 吴萍萍 申屠宝卿 CHENG Chao;WU Ping-ping;SHENTU Bao-qing(State Key Lab of Chemical Engineering,College of Chemical and Biological Engineering,Zhejiang University,Hangzhou 310027,China;Zhejiang Zhongcheng Packing Material Co.,Ltd.,Jiashan 314100,China;Zhejiang Zhongli Synethtic Material Technology Co.,Ltd.,Pinghu 314200,China)

机构地区：[1]浙江大学化学工程联合国家重点实验室化学工程与生物工程学院,浙江杭州310027 [2]浙江众成包装材料股份有限公司,浙江嘉善314100 [3]浙江众立合成材料科技股份有限公司,浙江平湖314200

出　　处：《精细化工中间体》2019年第5期10-14,共5页Fine Chemical Intermediates

摘　　要：以4-氯苯乙烯(4)为原料,采用叠缩工艺,经格氏反应、还原反应和氯代反应合成了单一结构的对氯甲基苯乙烯(4)。化合物4与镁屑生成格氏试剂,再与N,N-二甲基甲酰胺反应生成4-乙烯基苯甲醛(3)。化合物3与NaBH4-NaOH的溶液反应合成得到4-乙烯基苯甲醇(2)。在DMF催化作用下,化合物2与SOCl2和Et3N发生氯代反应生成对氯甲基苯乙烯(1),总收率达到52.6%。Telescoped process was developed for the synthesis of single structural p-chloromethyl styrene(4)which was prepared via Grignard reaction,reduction reaction and chlorination reaction using 4-chlorostyrene(4)as raw material.4-Vinylbenzaldehyde(3) was realized from compound 4 by treatment with magnesium and DMF in sequential order.Reduction reaction between compound 3 and NaBH4-NaOH solution afforded 4-vinylbenzyl alcohol(2).Chlorination reaction of compound 2 with SOCl2 and Et3 N gavep-chloromethyl styrene(1) in the presence of DMF as a catalyst with a total yield of 52.6%.

关 键 词：对氯甲基苯乙烯 单一结构 叠缩工艺 4-氯苯乙烯 

分 类 号：TQ242[化学工程—有机化工]