高压氧辅助放疗对胰腺癌患者的临床疗效及血浆肿瘤标志物的影响  

Clinical efficacy of radiotherapy combined with hyperbaric oxygen on the patients with pancreatic cancer and the impact on serum tumor markers

作　　者：安安[1] 侯良学[1] 孙永臣[1] An An;Hou Liangxue;Sun Yongchen(Department of Radiology,First People′s Hospital of Shangqiu,Shangqiu 476100,China)

机构地区：[1]商丘市第一人民医院放疗科,河南省商丘476100

出　　处：《中华航海医学与高气压医学杂志》2019年第6期533-536,共4页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

摘　　要：目的探究高压氧(HBO)辅助放疗对胰腺癌患者的临床疗效和血浆肿瘤标志物的影响。方法选取2015年1月至2017年9月河南省商丘市第一人民医院放疗科收治住院的84例中晚期胰腺癌患者作为研究对象,采用随机数字表法将84例胰腺癌患者分为对照组(n=42)和观察组(n=42)。对照组患者采取立体定向放疗,观察组患者则在对照组基础上加用HBO治疗。比较2组患者治疗前后血浆肿瘤标记物糖类抗原199(CA19-9)、缺氧诱导因子(HIF-1α)及血管内皮生长因子(VEGF)、临床疗效及不良反应。结果治疗后2组患者CA19-9、HIF-1α及VEGF含量较治疗前有明显降低,且观察组患者治疗后明显低于对照组(P<0.05)。观察组者患者总有效率(64.28%)明显高于对照组患者(40.48%)(P<0.05)。观察组患者骨髓抑制、肝功能损害、胃肠道反应明显低于对照组(P<0.05)。观察组和对照组患者2年总生存率、中位总生存期高于对照组,但差异无统计学意义(P>0.05)。结论HBO辅助放疗可通过下调CA19-9、HIF-1α及VEGF水平增加肿瘤细胞对放疗的敏感性,提高临床疗效,减少不良反应。Objective To explore the clinical efficacy of radiotherapy combined with hyperbaric oxygen(HBO)on the patients with pancreatic cancer and the impact on serum tumor markers.Methods Eighty-four patients with pancreatic cancer admitted into the hospital from January 2015 to September 2017 were selected as research objects,and were randomly and equally divided into the control group(n=42)and the observation group(n=42).The patients in the control group were given targeted radiotherapy,while the patients in the observation group were supplemented with HBO on the basis of the treatment as received by the control group.Then,plasma tumor marker carbohydrate antigen 199(CA19-9),hypoxia inducing factor(HIF-1α)and vascular endothelial growth factor(VEGF),as well as clinical efficacy and adverse reactions were compared between the 2 groups before and after treatment.Results After treatment,the contents of CA19-9,HIF-1αand VEGF in the 2 groups were significantly reduced compared with those before treatment,and those of the observation group were significantly better than those in the control group.Total effective rate of the observation group was 64.28%,which was higher than that of the control group(40.48%).Statistical significance could be noted,when comparisons were made between the 2 groups(P<0.05).Bone marrow suppression,hepatic function impairment and gastrointestinal reactions in the patients of the observation group were significantly lower than those of the control group(P<0.05).The 2-year overall survival rate and medium overall survival rate of the observation group were higher than those of the control group,but without statistical significance(P>0.05).Conclusion Radiotherapy combined with HBO therapy could increase radiotherapy response of tumor cells to radiotherapy through down-regulation of the levels of CA19-9,HIF-1αand VEGF,promote clinical efficacy,and further reduce adverse reactions.

关 键 词：放射治疗 高压氧 胰腺癌 肿瘤标记物 临床疗效 

分 类 号：R735[医药卫生—肿瘤]