高压氧联合减重步行训练在脑梗死恢复期患者中的应用价值  

Value of hyperbaric oxygen combined with weight-loss walking exercise in patients with cerebral infarction at recovery stage

作　　者：刘永芳[1] 齐林[2] 夏昱 李文建[3] 郭大志 魏建芬 潘树义 Liu Yongfang;Qi lin;Xia yu;Li Wenjian;Guo Dazhi;Wei Jianfen;Pan Shuyi(Department of Hyperbaric Oxygen Treatment Center,No.7 People′s Hospital of Zhengzhou,Zhengzhou 450016,China)

机构地区：[1]郑州市第七人民医院高压氧治疗中心,郑州450016 [2]郑州市第七人民医院医学检验科,郑州450016 [3]郑州市第七人民医院康复医学科,郑州450016 [4]解放军总医院第六医学中心高压氧科

出　　处：《中华航海医学与高气压医学杂志》2019年第6期561-563,共3页Chinese Journal of Nautical Medicine and Hyperbaric Medicine

基　　金：河南省医学科技攻关计划项目(2018020858)。

摘　　要：目的探究高压氧(HBO)联合减重步行训练在脑梗死恢复期患者中的应用价值。方法选取郑州市第七人民医院高压氧治疗中心2018年1月至2019年1月脑梗死恢复期患者90例,随机数字表法分为联合组(n=45)和对照组(n=45)。对照组行减重步行训练,联合组在对照组基础上联合HBO治疗。比较2组患者的治疗效果,神经生长因子(NGF)、神经元特异性烯醇化酶(NSE)、髓鞘碱性蛋白(MBP)水平及神经功能缺损评分(NIHSS)。结果联合组总有效率95.56%(43/45)高于对照组的73.33%(33/45),差异有统计学意义(P<0.05);治疗4周后,联合组血清NGF水平高于对照组,NSE、MBP低于对照组(P<0.05);治疗1周、4周后联合组NIHSS评分低于对照组(P<0.05)。结论HBO联合减重步行训练应用于脑梗死恢复期患者,可调节神经因子水平,降低神经功能损伤,康复效果显著。Objective To explore the application value of hyperbaric oxygen(HBO)combined with weight-loss walking exercise in patients with cerebral infarction at recovery stage.Methods Ninety patients with cerebral infarction at recovery stage treated in the hospital from January 2018 to January 2019 were enrolled for study,and were randomly divided into the combined group(n=45)and the control group(n=45).Results The control group received weight-loss walking exercise,while the combined group received HBO therapy on the basis of weight-loss walking exercise.Therapeutic effect,nerve growth factor(NGF),neuron specific enolase(NSE),myelin basic protein(MBP)and neurological function(NIHSS)scores were compared between the 2 groups.The total effective rate of the combined group was 95.56%(43/45),which was higher than that of the control group(73.33%)(33/45)(P<0.05).After 4 weeks of treatment,the NGF level of the combined group was higher than that of the control group,while the NSE and MBP levels of the combined group were lower than those of the control group(P<0.05),and the NIHSS scores of the combined group were lower than those of the control group after 1 and 4 weeks of treatment(P<0.05).Conclusion HBO combined with weight-loss walking exercise could regulate the levels of neurokines,alleviate neurological damage and achieve good recovery effects in the patients with cerebral infarction at recovery stage.

关 键 词：高压氧 减重步行训练 脑梗死 神经因子 

分 类 号：R74[医药卫生—神经病学与精神病学]