淋巴血管侵犯对根治性膀胱切除术病人预后影响  

INFLUENCE OF LYMPHOVASCULAR INVASION ON THE PROGNOSIS OF PATIENTS UNDERGOING RADICAL CYSTECTOMY

作　　者：周忠涵 官丰菊[1] 夏瑞琴[1] 任禹霏 孙立江[1] 张桂铭[1] ZHOU Zhonghan;GUAN Fengju;XIA Ruiqin;REN Yufei;SUN Lijiang;ZHANG Guiming(Urology Surgery,The Affiliated Hospital of Qingdao University,Qingdao 266003,China)

机构地区：[1]青岛大学附属医院泌尿外科,山东青岛266003 [2]青岛大学附属医院肿瘤科,山东青岛266003

出　　处：《青岛大学学报（医学版）》2020年第1期22-25,共4页Journal of Qingdao University(Medical Sciences)

基　　金：国家自然科学基金项目(81672512);山东省医药卫生科技发展计划项目(2016WS0258)

摘　　要：目的探讨淋巴血管侵犯(LVI)对行根治性膀胱切除术(RC)的非转移性膀胱癌病人预后的影响。方法回顾性分析79例行RC的非转移性膀胱癌病人的临床病理资料,分析LVI与各临床病理因素的关系,应用Kaplan-Meier法和多因素Cox等比例风险模型分析LVI对总生存期(OS)的影响。结果79例病人中位随访时间56.9个月,LVI阳性19例(24%)。23例病人死亡,包括10例LVI阳性病人及13例LVI阴性病人。LVI与年龄、性别、体质量指数、吸烟史、高血压史、糖尿病史、组织学分级、ECOG评分、是否合并原位癌、T分期无关(P>0.05)。LVI阳性病人的OS低于LV阴性病人(χ2=8.805,P<0.05)。多因素分析显示,年龄、T分期、LVI是影响OS的独立危险因素(HR=0.349~11.901,P<0.05)。结论LVI是影响行RC的非转移性膀胱癌病人OS的独立危险因素。Objective To investigate the influence of lymphovascular invasion(LVI)on the prognosis of patients with non-metastatic bladder cancer(BCa)undergoing radical cystectomy(RC).Methods A retrospective analysis was performed for the clinicopathological data of 79 patients with non-metastatic BCa who underwent RC,and the association of LVI with each clinicopathological factor was analyzed.The Kaplan-Meier method and the multivariate Cox proportional hazards regression model were used to assess the influence of LVI on overall survival(OS).Results The median follow-up of the 79 patients was 56.9 months,and of all patients,19(24%)had LVI.A total of 23 patients died,among whom 10 had LVI and 13 did not have LVI.LVI was not associated with age,sex,body mass index,smoking history,history of hypertension and/or diabetes,histological grade,ECOG score,presence or absence of tumor in situ,and T stage of tumor(P>0.05).The patients with LVI had significantly shorter OS than those without LVI(χ2=8.805,P<0.05).The multivariate analysis showed that age,T stage of tumor,and LVI were independent risk factors for OS(HR=0.349-11.901,P<0.05).Conclusion LVI may be an independent risk factor for OS in patients with non-metastatic BCa undergoing RC.

关 键 词：膀胱肿瘤 膀胱切除术 淋巴血管侵犯 预后 

分 类 号：R737.14[医药卫生—肿瘤]