新型抗强迫药物艾司西酞普兰治疗强迫症的有效性分析  

Analysis of the effectiveness of new anti-obsessive drug escitalopram in the treatment of obsessive-compulsive disorder

作　　者：苗贞勇 Miao Zhenyong(Department of Psychiatry,Panjin Liaoyou Gem Flower Hospital,Panjing,Liaoning,124000,China)

机构地区：[1]盘锦辽油宝石花医院精神科

出　　处：《当代医学》2020年第8期43-45,共3页Contemporary Medicine

摘　　要：目的分析新型抗强迫药物艾司西酞普兰治疗强迫症的有效性。方法选择2017年2月至2019年2月本院收治的60例强迫症患者,按照住院单双号不同分为对照组与研究组,各30例。对照组患者给予传统的抗强迫症药物氯米帕明(口服,每天50 mg)治疗,研究组患者则给予艾司西酞普兰(口服,每天5 mg)治疗。对比两组患者治疗前后的耶鲁布朗强迫症量表评分,评估两种药物的有效性和安全性。结果研究组患者的总有效率为93.33%,对照组的总有效率为86.66%,组间比较差异无统计学意义。治疗前两组患者的耶鲁布朗强迫症量表评分比较差异无统计学意义。治疗后两组患者的耶鲁布朗强迫症量表评分均明显低于治疗前,差异有统计学意义(P<0.05)。治疗后研究组患者的耶鲁布朗强迫症量表评分为(14.2±2.7)分,对照组患者的耶鲁布朗强迫症量表评分为(14.9±3.0)分,组间对比差异无统计学意义。治疗后研究组患者的不良反应发生率为10.00%,显著低于对照组的43.33%,组间对比差异具有统计学意义(P<0.05)。结论新型抗强迫药物艾司西酞普兰与传统的抗强迫症药物氯米帕明治疗强迫症均具有显著疗效,均可有效改善患者的强迫症症状,值得在临床上进行推广。Objective To analyze the effectiveness of a new anti-obsessive drug, escitalopram, in the treatment of obsessive-compulsive disorder.Methods 60 cases of obsessive-compulsive disorder patients admitted to our hospital from February 2017 to February 2019 were selected, and all patients were divided into control group and study group according to the hospitalized single and double numbers, with 30 cases in each group. Patients in the control group were treated with the traditional anti-obsessive drug clomipramine(oral, 50 mg per day), while the study group was given escitalopram(oral, 5 mg per day) treatment. The Yale Brown Obsessive-compulsive Scale scores before and after treatment were compared between the two groups to assess the efficacy and safety of the two drugs. Results The total effective rate of the study group was 93.33%, and the total effective rate of the control group was 86.66%. There was no significant difference between the groups. There was no significant difference in the scores of the Yale-Brown Obsessive-compulsive Scale between the two groups before treatment. After treatment, the scores of the Yale-Brown Obsessive-compulsive Scale were significantly lower than those before treatment, and the difference was statistically significant(P<0.05). After treatment, the Yale-Brown Obsessive-compulsive Scale score was(14.2±2.7) in the study group, and the Yale-Brown Obsessive-compulsive Disorder Scale in the control group was(14.9±3.0). The difference between the groups was not statistically significant. After treatment, the incidence of adverse reactions in the study group was 10.00%, which was significantly lower than that in the control group of 43.33%. The difference between the two groups was statistically significant(P<0.05). Conclusion The new anti-obsessive drug escitalopram and the traditional anti-obsessive drug clomipramine have significant curative effect on obsessive-compulsive disorder, and can effectively improve the symptoms of obsessive-compulsive disorder in patients. It is worthy o

关 键 词：抗强迫药物 艾司西酞普兰 氯米帕明 有效性 安全性 

分 类 号：R749.7[医药卫生—神经病学与精神病学]