胎儿生长受限的氨基酸代谢学研究  

Study of Amino acids metabolism status of fetal growth restriction

作　　者：刘倩[1] 饶腾子[1] 沈文 谢讯杰 赵馨[1] 朱冬生[4] LIU Qian;RAO Teng-zi;SHEN Wen

机构地区：[1]广东省妇幼保健院医学遗传中心,广东广州510010 [2]广东省妇幼保健院生殖中心,广东广州510010 [3]广东省妇幼保健院儿童遗传代谢与内分泌科,广东广州510010 [4]广东省妇幼保健院儿童保健科,广东广州510010

出　　处：《中国产前诊断杂志（电子版）》2019年第4期42-45,共4页Chinese Journal of Prenatal Diagnosis(Electronic Version)

基　　金：广东省医学科研基金（201611423161532）

摘　　要：目的探讨宫内生长受限胎儿体内氨基酸在胎儿生长发育过程中意义。方法采取病例对照研究方法,分析广东省妇幼保健院2014年12月至2018年12月进行脐血产前诊断的胎儿86例,其中病例组30例,对照组56例。采用高效液相色谱-串联质谱检测所有胎儿脐血干血片中11种氨基酸浓度,采用t检验或秩和检验方法比较2组氨基酸浓度差异。结果生长受限组各氨基酸浓度均低于对照组,其中Phe、Tyr、Pro等氨基酸浓度两组间差异有统计学意义。结论生长受限胎儿的Phe、Tyr、Pro等氨基酸在疾病的发生发展中发挥重要作用。Objective To explore the significance of amino acids in intrauterine growth-limiting fetuses during fetal growth and development.Method We conducted case-control study to analyze 86 cases of prenatal diagnosis of umbilical cord blood from December,2014 to December,2018,including 30 cases in the case group and 56 cases in the control group.The concentration of 11 amino acids in all fetal cord blood dried blood samples was detected by high performance liquid chromatography-tandem mass spectrometry.The difference of amino acid concentrations between the two groups was compared by t test or rank sum test.Results The concentration of each amino acid in the growth-restricted group was lower than that in the control group.The difference of amino acid concentrations such as Phe,Tyr and Pro was statistically significant.Conclusions Growth-limited amino acids such as taier de Phe,Tyr,and Pro play important roles in the occurrence and development of diseases.

关 键 词：氨基酸 胎儿宫内生长受限 

分 类 号：R714.53[医药卫生—妇产科学]