CT图像纹理分析鉴别诊断腮腺混合瘤与腺淋巴瘤  

CT Texture Analysis in the Differential Diagnosis of Mixed Tumor of Parotid Gland and Adenolymphoma

作　　者：刘文华 张衡[1] 李敏 任国强[1] 耿兴东[1] 王昕 唐志洋[1] 蒋敏[1] LIU Wenhua;ZHANG Heng;LI Min(Department of Medical Imaging,Jiangsu University Affiliated People’s Hospital,Zhenjiang 212002,P.R.China)

机构地区：[1]江苏大学附属人民医院影像科

出　　处：《临床放射学杂志》2019年第12期2271-2274,共4页Journal of Clinical Radiology

摘　　要：目的探讨CT纹理分析技术鉴别诊断腮腺混合瘤与腺淋巴瘤的应用价值。方法回顾性分析病理证实的39例腮腺混合瘤与32例腮腺腺淋巴瘤CT平扫图像的纹理特征,在肿瘤最大截面的轴面图像上手动勾画感兴趣区(ROI),应用纹理分析方法测定熵、标准差、对比、偏度、峰态、逆差矩、角二阶矩、相关8个纹理参数,并测量肿瘤长径。采用独立样本t检验(正态分布且方差齐)或Mann-Whitney U检验(非正态分布或方差不齐)比较腮腺混合瘤与腺淋巴瘤纹理参数、肿瘤长径的差异。采用受试者工作特征(ROC)曲线分析有统计学意义的参数预测纹理分析的效能。P<0.05为差异有统计学意义。结果两组患者间肿瘤的偏度(t=2.10)、峰态(t=-2.13)和肿瘤长径(t=2.58)的差异均有统计学意义(P均<0.05),纹理参数值偏度、峰态和病灶直径的ROC曲线下面积(AUC)值分别0.63、0.64和0.70(P均<0.05)。病灶直径联合纹理特征鉴别诊断腮腺混合瘤与腺淋巴瘤的AUC值为0.74(P<0.05);病灶直径联合纹理特征鉴别诊断腮腺混合瘤与腺淋巴瘤敏感度68.4%、特异度79.5%。两者间熵、标准差、对比、逆差矩、角二阶矩、相关均无统计学意义(P>0.05)。结论图像纹理参数对腮腺混合瘤与腺淋巴瘤的鉴别诊断有一定作用,且联合肿瘤长径可提高鉴别诊断效能。Objective To study the value of CT texture analysis in the differential diagnosis of mixed tumor of parotid gland and adenolymphoma.Methods The plain CT texture features of 39 cases of mixed tumor of parotid gland and 32 cases of adenolymphoma confirmed by pathology were analysed retrospectively.The region of interest(ROI)was draftedon the shaft surface images of the tumor maximum cross section,then eight texture parameters such as entropy,standard devia-tion,contrast,skewness,kurtosis,deficit torque,angular second moment and correlation were measured,and the tumor long-axis diameters were also measured.The differences of texture parameters and the tumor long-axis diameters between mixed tumor of parotid gland and adenolymphoma were compared by independent sample t test(normal distribution and homogeneity of variance)or mann-whitney U test(non-normal distribution or heterogeneity of variance).ROC curve analy-sis was used to predict the effectiveness of texture analysis with statistically significant parameters.P<0.05 was considered statistically significant.Results The differences of tumor skewness(t=2.10),kurtosis(t=-2.13)and tumor long-axis diameters(t=2.58)between the two groups was statistically significant(P<0.05).The areas(AUC)under the ROC curve of skewness,kurtosis and lesion long-axis diameters were 0.63,0.64 and 0.70,respectively(P<0.05,re-spectively).The AUC value of the lesion long-axis diameter combined with the texture feature to differential diagnosis of mixed tumor of parotid gland and adenolymphoma was 0.74(P<0.05);and the sensitivity and specificity was 68.4%and 79.5%,respectively.However,the differences of entropy,standard deviation,contrast,deficit torque,angular second moment and correlation between the two groups were not statistically significant(P>0.05).Conclusion The CT texture analysis has certain effect on the differential diagnosis of mixed tumor of parotid gland and adenolymphoma,and the com-bined measurement of tumor long-axis diameter can improve the efficiency of differential diagn

关 键 词：腮腺肿瘤 混合瘤 腺淋巴瘤 体层摄影术 X线计算机 纹理分析 

分 类 号：R739.8[医药卫生—肿瘤] R730.44[医药卫生—临床医学]