Concise,enantioselective total syntheses of both the proposed and revised structures of (-)-versiquinazoline H  

作　　者：Jiang-Feng Wu Pei-Qiang Huang 

机构地区：[1]Department of Chemistry,Fujian Provincial Key Laboratory of Chemical Biology,College of Chemistry and Chemical Engineering,Xiamen University

出　　处：《Chinese Chemical Letters》2020年第1期61-63,共3页中国化学快报（英文版）

基　　金：financial support from the National Natural Science Foundation of China (Nos.21672176 and 21332007);the National Key R&D Program of China (No. 2017YFA0207302)

摘　　要：The enantioselective total synthesis of the putative structure of versiquinazoline H and three diastereomers has been achieved,which allowed the revision of the stereochemistry of this natural product.This six-step total synthesis relied on the evolution of the strategy that we previously developed,which features a DMDO-triggered tandem reaction.The modification of the lactamization step resulted in a significant improvement of yield that ensured the efficient total synthesis.The enantioselective total synthesis of the putative structure of versiquinazoline H and three diastereomers has been achieved,which allowed the revision of the stereochemistry of this natural product.This six-step total synthesis relied on the evolution of the strategy that we previously developed,which features a DMDO-triggered tandem reaction.The modification of the lactamization step resulted in a significant improvement of yield that ensured the efficient total synthesis.

关 键 词：ALKALOIDS Total synthesis Tandem reaction Structural revision Protecting group-free 

分 类 号：O621.3[理学—有机化学]