降钙素原、乳酸及C反应蛋白在重症肺炎中的变化及意义  被引量:1

Changes and Significance of Procalcitonin, Lactic Acid and C-reactive Protein in Severe Pneumonia

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作  者:李国明[1] LI Guo-ming(Department of Emergency,Jiangmen Central Hospital,Jiangmen 529030,Guangdong,China)

机构地区:[1]江门市中心医院急诊科

出  处:《医学信息》2020年第2期70-72,共3页Journal of Medical Information

摘  要:目的分析不同时间重症肺炎(SP)患者降钙素原(PCT)、乳酸(Lac)和C-反应蛋白(CRP)水平的变化及其意义。方法选择2016年1月~2018年12月我院收治的67例SP患者,分别在患者入院后的第1、3、7天以及好转出科或死亡前检测PCT、Lac及CRP水平,同时行APACHE-Ⅱ评分。根据患者预后情况分为存活组(48例)和死亡组(19例)。比较两组不同时间血清PCT、Lac、CRP水平及其与APACHE-Ⅱ评分的相关性。结果存活组第3、7天以及好转出科前PCT、Lac、CRP、APACHE-Ⅱ评分均低于第1天(P<0.05);死亡组第3、7天以及死亡前PCT、Lac、CRP、APACHE-Ⅱ评分均高于第1天(P<0.05);死亡组不同时间PCT、Lac、CRP、APACHE-Ⅱ评分均高于存活组(P<0.05)。重症肺炎患者血清PCT、Lac、CRP与APACHE-Ⅱ评分呈正相关(r=0.721、0.613、0.814,P<0.05)。结论PCT、Lac、CRP与SP的病情程度有关,病情越严重,血清水平越高;动态监测PCT、Lac、CRP及APACHE-Ⅱ评分有助于病情和预后的判断。Objective To analyze the changes of procalcitonin(PCT),lactic acid(Lac)and C-reactive protein(CRP)levels in patients with severe pneumonia(SP)at different times and their significance.Methods A total of 67 patients with SP who were admitted to our hospital from January 2016 to December 2018 were selected.PCT,Lac,and CRP levels were measured on the 1,3,and 7 days after admission,and before they were discharged from the department or died.At the same time,APACHE-Ⅱscore was performed.According to the prognosis of patients,they were divided into survival group(48 cases)and death group(19 cases).The serum PCT,Lac,CRP levels and their correlation with APACHE-Ⅱscore were compared between the two groups at different times.Results The PCT,Lac,CRP,and APACHE-Ⅱscores of patients in the survival group on the 3rd and 7th days and before the transfer were lower than those on the 1st day(P<0.05);The PCT,Lac,CRP,and APACHE-Ⅱscores of patients in the death group on the third and seventh days and before death were higher than those on the first day(P<0.05);the PCT,Lac,CRP,and APACHE-Ⅱscores of the death group were high at different times In the survival group(P<0.05).There was a positive correlation between serum PCT,Lac and CRP and APACHE-Ⅱscores in patients with severe pneumonia(r=0.721,0.613,0.814,P<0.05).Conclusion PCT,Lac,and CRP are related to the severity of SP.The more severe the disease,the higher the serum level.Dynamic monitoring of PCT,Lac,CRP,and APACHE-Ⅱscores is helpful to judge the disease and prognosis.

关 键 词:降钙素原 乳酸 C-反应蛋白 APACHE-Ⅱ评分 重症肺炎 

分 类 号:R563.1[医药卫生—呼吸系统]

 

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