卵巢Sertoli细胞瘤临床病理特征分析  

Analysis of Clinicopathological Characteristics of Ovarian Sertoli Cell Tumor

作　　者：张秀梅 侯兴华[2] 赵俊军 ZHANG Xiu-mei;HOU Xing-hua;ZHAO Jun-jun(Department of Pathology,Dalian Central Hospital,Dalian Medical University,Dalian 116033,Liaoning,China;Department of Pathology,Anshan Central Hospital,Anshan 114000,Liaoning,China)

机构地区：[1]大连医科大学附属大连市中心医院病理科,辽宁大连116033 [2]鞍山市中心医院病理科,辽宁鞍山114000

出　　处：《医学信息》2020年第2期176-178,共3页Journal of Medical Information

摘　　要：目的探讨2例卵巢Sertoli细胞瘤的临床病理特征、免疫表型、诊断、鉴别诊断及预后。方法回顾性分析2012年1月~2018年12月于我院手术切除的2例卵巢Sertoli细胞瘤的临床特征、组织学特点及免疫表型,并复习相关文献。结果病例1,女性,54岁,超声检查发现左附件区12.5 cm×10.9 cm×10.3 cm囊实混合性肿物。病例2,女性,22岁,超声检查示右卵巢5.5 cm×4.5 cm×4.0 cm肿物。镜下肿瘤细胞排列成实性片状、条索状、中空和实性小管状结构,瘤细胞圆形、卵圆形或梭形,胞质丰富淡染,无明显异型性,核分裂像罕见,未见Leydig细胞。免疫组化示α-inhibin、WT1阳性,CR、CK灶状阳性,CD99、EMA、Syn、CgA阴性。2例患者随访时间分别为22个月及19个月,一般状态良好,未见复发和转移。结论卵巢Sertoli细胞瘤罕见,通常为良性生物学行为,结合临床病史、组织学形态及免疫组化染色可做出病理诊断。Objective To investigate the clinicopathological characteristics,immunophenotype,diagnosis,differential diagnosis and prognosis of 2 cases of ovarian Sertoli cell tumor.Methods The clinical characteristics,histological characteristics,and immunophenotype of 2 cases of ovarian Sertoli cell tumor surgically resected from January 2012 to December 2018 were retrospectively analyzed,and the relevant literatures were reviewed.Results Case 1,female,54 years old.Ultrasound revealed a 12.5 cm×10.9 cm×10.3 cm cystic solid mass in the left appendage area.Case 2,female,22 years old.Ultrasonography showed a 5.5 cm×4.5 cm×4.0 cm mass in the right ovary.Under the microscope,tumor cells are arranged into solid sheet-like,strand-like,hollow,and solid small tubular structures.The tumor cells are round,oval,or spindle-shaped.The cytoplasm is rich and lightly stained.No Leydig cells were seen.Immunohistochemistry showedα-inhibin,WT positive,CR,CK focal positive,CD99,EMA,Syn,CgA negative.The two patients were followed up for 22 months and 19 months,respectively,and generally in good condition without recurrence and metastasis.Conclusion Ovarian Sertoli cell tumors are rare and usually benign biological behaviors.Combining clinical history,histological morphology,and immunohistochemical staining can make pathological diagnosis.

关 键 词：卵巢 Sertoli细胞瘤 免疫组化 鉴别诊断 

分 类 号：R737.31[医药卫生—肿瘤]