浅谈胃癌转化医学研究的"瑞金体会"  

Translational research on gastric cancer:Ruijin experience

作　　者：李建芳[1] 朱正纲[1] 刘炳亚[1] Li Jianfang;Zhu Zhenggang;Liu Bingya(Department of Surgery,Ruijin Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai Institute of Digestive Surgery,Shanghai Key Laboratory of Gastric Neoplasms,Shanghai 200025,China)

机构地区：[1]上海交通大学医学院附属瑞金医院外科,上海消化外科研究所,上海市胃肿瘤重点实验室,200025

出　　处：《中华胃肠外科杂志》2020年第2期140-143,共4页Chinese Journal of Gastrointestinal Surgery

摘　　要：转化医学是指将医学生物学基础研究成果迅速有效地转化为可在临床实际应用的理论、技术、方法和药物。目前胃癌的临床诊治仍存在很多问题需要解决,如何以临床急需解决的问题为出发点,以提高患者诊疗效果为宗旨,以基础研究为基本手段,以多学科交叉融合为途径,加强转化医学研究,是进一步提高胃癌总体疗效的关键所在。本文从瑞金医院团队转化研究经验出发,对胃癌的病因与发病机制、早期诊断的肿瘤标志物、复发转移的预测、分型标准、化疗评估、肿瘤异质性、靶向治疗、免疫治疗及研究平台的建立等目前胃癌转化医学研究的重点发展方向进行了介绍,并就胃癌血清标志物、胃癌特异性抗体研究以及改善胃癌药物输送手段等转化研究,分享作者的看法。Translational medicine refers to translating basic research achievements into the clinical application for diagnosis and treatment.There are still many issues of gastric cancer to be solved in clinical diagnosis and treatment.We need to focus on clinical questions,by means of basic research and multidisciplinary intersection approach,to further improve the overall efficacy of gastric cancer.Based on Ruijin Hospital′s translational research experiences,in this paper,the authors describe the future direction in the field of translational research,such as the etiology and pathogenesis of gastric cancer,tumor markers for early diagnosis,prediction of recurrence and metastasis,classification criteria,evaluation of chemotherapy,tumor heterogeneity,targeted therapy,immunotherapy and research platform establishment.In addition,here we share our perspective of the research on serum biomarkers,specific antibodies and improvement of drug delivery for gastric cancer.

关 键 词：胃肿瘤 转化医学 生物学标记 抗体 药物载体 

分 类 号：R735[医药卫生—肿瘤]