皮下注射rhGM-CSF联合静脉滴注rhIL-2在减轻食管癌放疗患者放射性食管炎中的作用  

rhGM-CSF subcutaneously combined with rhIL-2 intravenous drip for relieving radiation esophagitis in patients with esophageal cancer undergoing radiotherapy

作　　者：葛琴[1] 王高仁 谢国栋[1] 卑源琪[1] 顾红芳[1] 葛方红[1] 王兴丹 GE Qin;WANG Caoren;XIE Cuodong;BEI Yuanqi;CU Hongfang;GE Fanghong;WANG Xingdan(Department of Radiation Oncology,Nantong Tumor Hospital,Nantong 226361,Jiangsu Province,China)

机构地区：[1]南通市肿瘤医院放疗科

出　　处：《肿瘤》2019年第12期1004-1010,共7页Tumor

摘　　要：目的:探讨皮下注射重组人粒细胞/巨噬细胞集落刺激因子(recombinant human granulocyte-macrophage colony-stimulating factor,rhGM-CSF)联合静脉滴注重组人白细胞介素2(recombinant human interleukin-2,rhIL-2)对食管癌放疗患者放射性食管炎的影响。方法:将70例食管癌患者随机分为观察组和对照组,观察组(皮下注射rhGM-CSF联合静脉滴注rhIL-2+放疗)35例,对照组(单纯放疗)35例。比较2组患者放射性食管炎发生情况、疼痛程度、干预措施及治疗依从性等。结果:放疗后发生3~4级放射性食管炎的患者中,观察组有3例,对照组有12例(P <0.05);放射性食管炎引起吞咽疼痛,观察组发生7分以上疼痛的患者明显少于对照组(P <0.05);观察组患者使用针对放射性食管炎的干预药物明显少于对照组(P <0.05);观察组患者治疗后出现恶心、呕吐、食欲不振、疼痛和失眠等情况明显好于对照组(P值均<0.05);观察组无放疗中断患者,对照组有3例患者中断放疗(P <0.05)。结论:皮下注射rhGM-CSF联合静脉滴注rhIL-2后发生放射性食管炎相关症状的患者明显减少,吞咽疼痛的减轻改善了患者的生活质量,同时提高了患者的治疗依从性。Objective: To investigate the effect of subcutaneous injection of recombinant human granulocyte-macrophage colony-stimulating factor(rhGM-CSF) combined with intravenous drip of recombinant human interleukin-2(rhIL-2) on radiation esophagitis in the patients with esophageal cancer undergoing radiotherapy.Methods: Seventy patients with esophageal cancer were randomly divided into the experimental group and the control group. Thirty-five patients in the experimental group were treated with subcutaneous injection of rhGM-CSF combined with intravenous drip of rhIL-2 and radiotherapy, while 35 patients in the control group were just treated with radiotherapy alone. The occurrence of radiation esophagitis, the degree of pain, intervention measures and treatment compliance were compared between the two groups.Results: There were 3 cases with grade 3 or 4 radiation esophagitis in the experimental group, and 12 cases in the control group(P < 0.05). The number of patients with swallowing pain(more than 7 points) caused by radiation esophagitis in the experimental group was significantly less than that in the control group(P < 0.05). The number of patients used the intervention drugs of radiation esophagitis in the experimental group was significantly less than that in the control group(P < 0.05). After the treatment, the nausea and vomiting, loss of appetite, pain, and insomnia in the experimental group were significantly better than those in the control group(all P < 0.05). There was no interruption of radiotherapy in the experimental group, while the radiotherapy of 3 cases in the control group was interrupted(P < 0.05).Conclusion: Subcutaneous injection of rhGM-CSF combined with intravenous drip of rhIL-2 significantly reduce the proportion of radiation esophagitis-related symptoms in the patients with esophageal cancer, improve the quality of life by reliving the swallowing pain, as well as improve the treatment compliance of patients.

关 键 词：食管肿瘤 化放疗 食管炎 粒细胞巨噬细胞集落刺激因子 白细胞介素2 

分 类 号：R735.1[医药卫生—肿瘤]