铜绿假单胞菌注射液治疗乳腺癌术后顽固性皮下积液的疗效观察  

Observation on the effect of pseudomonas aeruginosa preparation in treating refractory seroma after breast cancer surgery

作　　者：冯小娟[1] 钟善琼[1] 曾媛媛 吕青[1] 李卡[2] FENG Xiaojuan;ZHONG Shanqiong;ZENG Yuanyuan;LÜQing;LI Ka(Department of Breast Surgery,West China Hospital of Sichuan University,Chengdu 610041,P.R.China;West China Nursing School of Sichuan University,Chengdu 610041,P.R.China)

机构地区：[1]四川大学华西医院乳腺外科,成都610041 [2]四川大学华西护理学院,成都610041

出　　处：《中国普外基础与临床杂志》2020年第3期304-308,共5页Chinese Journal of Bases and Clinics In General Surgery

基　　金：四川省科技厅项目（项目编号：2019YFH0146）

摘　　要：目的探讨铜绿假单胞菌注射液治疗乳腺癌术后顽固性皮下积液的有效性和安全性。方法前瞻性收集2018年10月至2019年8月期间四川大学华西医院收治的76例乳腺癌术后发生顽固性皮下积液的患者,随机分为2组,对照组(n=36)在积液腔低位安置留置针接负压引流器,试验组(n=40)在对照组基础上将铜绿假单胞菌注射液注入积液腔,比较2组患者的引流时间、总引流量、皮下积液复发率和并发症发生率。结果试验组有4例、对照组有3例失访,共69例患者的临床资料纳入分析。试验组患者的引流时间较对照组短,总引流量较对照组少,皮下积液复发率较对照组低,差异均有统计学意义(P<0.05),但2组患者的各并发症发生率(包括发热、积液区皮肤红肿和切口感染)比较差异均无统计学意义(P>0.05)。结论铜绿假单胞菌注射液治疗乳腺癌术后顽固性皮下积液的疗效确切,能缩短引流时间,促进伤口愈合。Objective To observe the effectiveness and safety of pseudomonas aeruginosa preparation in treating refractory seroma after breast cancer surgery.Methods A total of 76 patients with refractory seroma after breast cancer surgery who underwent surgery from October 2018 to August 2019 in our hospital were selected.The subjects were randomly divided into two groups.The patients in the control group(n=36)adopted negative pressure drainage connected with indwelling needle in the lower position of the seroma chamber;on the basis,patients in the experimental group(n=400)were injected with pseudomonas aeruginosa preparation into the seroma chamber.The drainage time,total drainage volume,recurrence rate,and incidence of complications of the two groups were compared.Results There were 4 cases in the experimental group and 3 cases in the control group were lost followed-up,so only 69 cases enrolled in data analysis.The drainage time,total drainage volume,and the recurrence rate of the experimental group were all shorter or less than those of the control group(P<0.05).But there was no significant difference in the incidence of complications between the experimental group and the control group(P>0.05),such as fever,inflamed skin,and infection of incision.Conclusion Pseudomonas aeruginosa preparation is an effective treatment for refractory seroma after breast cancer surgery,which can shorten the drainage time and promote wound healing.

关 键 词：皮下积液 铜绿假单胞菌注射液 乳腺癌 

分 类 号：R737.9[医药卫生—肿瘤]