雌激素代谢与乳腺癌关系的研究进展  

Research progress on the relationship between estrogen metabolism and breast cancer

作　　者：方玲[1] 羊晓勤[1] 李宏江[1] FANG Ling;YANG Xiaoqin;LI Hongjiang(Department of Breast Surgery,West China Hospital,Sichuan University,Chengdu 610041,R.P.China)

机构地区：[1]四川大学华西医院乳腺外科

出　　处：《中国普外基础与临床杂志》2020年第3期374-378,共5页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的探讨女性雌激素代谢与乳腺癌之间的关系。方法通过检索中国知网、万方数据库、PubMed等数据库中相关内容,从乳腺癌激素受体状态和月经状态对雌激素代谢的影响与乳腺癌的关系,雌激素在体内代谢途径及信号转导等方面文献进行综述。结果雌激素及其代谢产物与乳腺癌的发生发展密切相关。在雌激素主要的几条代谢途径中,2-羟基代谢途径中的2-甲氧基雌二醇对乳腺癌的发生具有潜在的保护作用;而4-羟基雌二醇、16α-羟基雌酮的产生可能会诱导乳腺癌的发生;4-羟基雌二醇与2-羟基雌二醇比例可能被用作预测恶性乳腺肿瘤的生物标志物。然而绝经前后雌激素代谢模式不同,对激素受体状态影响也不尽相同,不同激素受体状态会影响乳腺癌的治疗及预后。结论雌激素及其代谢产物与不同受体状态乳腺癌的关系尚不完全明确,还需要更多大规模前瞻性研究帮助我们找到其规律,从而促进乳腺癌的早期诊断和早期预防。Objective To investigate the relationship between female estrogen metabolism and breast cancer.Method By searching the contents of Chinese Knowledge Network,Wanfang Database,PubMed and other databases,the relationship between breast cancer hormone receptor status,menstrual status and estrogen metabolism and breast cancer,estrogen metabolism pathway and signal in vivo a review of the transduction aspects.Results Estrogen and its metabolites was closely related to the occurrence and development of breast cancer.Among the main metabolic pathways of estrogen,2-methoxyestradiol in the 2-hydroxy metabolic pathway had a potential protective effect on breast cancer;4-hydroxyestradiol,16α-hydroxyestrone might induce breast cancer;the ratio of 4-hydroxyestradiol to 2-hydroxyestradiol might be used as a biomarker for predicting malignant breast tumors.However,the estrogen metabolism patterns before and after menopause were different,and the effects on hormone receptor status were also different.Different hormone receptor status might affect the treatment and prognosis of breast cancer.Conclusions The relationship between estrogen and its metabolites and breast cancer in different receptor states is not completely clear.More large-scale prospective studies are needed to help us find out the rules to promote early diagnosis and early prevention of breast cancer.

关 键 词：雌激素 乳腺癌 综述 

分 类 号：R737.9[医药卫生—肿瘤]