药源性骨软化及佝偻病的发病机制、致病药物和防治  

Mechanism and prevention of drug-induced osteomalacia and rickets

作　　者：孙搏 徐瑛 刘皋林[2] SUN Bo;XU Ying;LIU Gao-lin(Shanghai Center for Drug Evaluation and Inspection,Shanghai 201203;Shanghai General Hosptial,School of Medicine,Shanghai Jiaotong University,Shanghai 200080)

机构地区：[1]上海药品审评核查中心,上海201203 [2]上海交通大学附属第一人民医院,上海200080

出　　处：《中南药学》2020年第1期84-88,共5页Central South Pharmacy

基　　金：国家重点研发计划资助项目(No.2017YFC0909900)

摘　　要：由药物引发的疾病是药物的意外作用,可造成正常器官或组织的病理损害,称为药源性疾病。骨软化症和佝偻病是新形成的骨基质不能进行正常矿化的代谢性骨病。有些药物也会引起骨软化症和佝偻病,称为药源性骨软化症及佝偻病。本篇文章介绍药源性骨软化及佝偻病的致病机制、主要致病药物、预防及治疗。A drug-induced disease is the unintended effect of a drug,which may cause pathological damage to a normal organ or tissue.Osteomalacia and rickets are metabolic bone diseases in which the newly formed bone matrix cannot be normally mineralized.Some drugs can cause osteomalacia and rickets,known as drug-induced osteomalacia and rickets.This article introduces the pathogenic mechanism,major pathogenic drugs,prevention and treatment of drug-induced osteomalacia and rickets.

关 键 词：药源性骨软化 药源性佝偻病 药源性疾病 

分 类 号：R730[医药卫生—肿瘤]