星形胶质细胞膜电位门控钙离子通道调控神经元癫痫放电  

VOlTAGE-GATED CALCIUM CHANNELS IN ASTRCOCYTES REGULATING EPILEPTIC SEIZURES

作　　者：独盟盟 袁治轩 李佳佳 吴莹[1,2] Du Mengmeng;Yuan Zhixuan;Li Jiajia;Wu Ying(School of Aerospace Engineering,State Key Laboratory for Strength and Vibration of Mechanical Structures,Xi’an Jiaotong University,Xi’an 710049 China;National Demonstration Center for Experimental Mechanics Education,Xi’an Jiaotong University,Xi’an 710049 China)

机构地区：[1]西安交通大学机械结构强度与振动国家重点实验室,航天航空学院,西安710049 [2]西安交通大学力学实验教学国家示范中心,西安710049

出　　处：《动力学与控制学报》2020年第1期49-55,共7页Journal of Dynamics and Control

基　　金：国家自然科学基金资助项目(11772242)~~

摘　　要：细胞外空间钾离子的大量积累会导致星形胶质细胞膜去极化,星形胶质细胞膜电位变化引起的电压门控钙离子通道(VGCCs)电流内流会增加星形胶质细胞内钙离子浓度的振荡幅值,从而增强星形胶质细胞对神经元的正反馈作用。考虑星形胶质细胞VGCCs的钙离子内流,本文构建了一种包含多种离子浓度动力学行为的神经元-胶质细胞耦合模型。数值模拟结果发现,VGCCs的钙离子内流是影响星形胶质细胞内Ca^2+浓度升高的一个主要因素;VGCCs电流增强会诱发神经元产生自发性癫痫放电活动实验现象的内在机理。本文研究结果可以为星形胶质细胞钙离子代谢紊乱诱发神经系统自发性癫痫放电提供一种解释。The accumulation of extracellular potassium(K^+)concentration induces astrocytes membrane depolarization,which causes the voltage-gated calcium channel(VGCCs)current flow into astrocyte and increases the level of calcium concentration in astrocyte,thus enhancing the positive feedback effect of astrocyte on neuron.In this work,we presented a neuron-astrocyte coupled model consisting of ions concentration dynamics.Our model validated experimental recordings that Ca^2+influx through VGCCs is a major factor in the increase of Ca^2+concentration in astrocyte and revealed the internal mechanism that enhanced VGCCs current could induce spontaneous epileptic discharges in the absence of external stimulus input.The results in this work will provide an explanation for Ca^2+metabolism disorders of astrocytes can induce spontaneous epilepsy discharges.

关 键 词：星形胶质细胞 VGCCs 钙离子 癫痫 

分 类 号：R742.1[医药卫生—神经病学与精神病学]