前包钦格复合体中钙动力学对放电模式的影响  

EFFECTS OF CALCIUM DYNAMICS ON FIRING ACTIVITIES IN THE PRE-B?TZINGER COMPLEX

作　　者：梁桐桐 段利霞[1] 赵雅琪 赵勇[2] Liang Tongtong;Duan Lixia;Zhao Yaqi;Zhao Yong(School of Science,North China University of Technology,Beijing 100144,China;School of Mathematics and Information Science,Henan Polytechnic University,Jiaozuo 454000,China)

机构地区：[1]北方工业大学理学院,北京100144 [2]河南理工大学数学与信息科学学院,焦作45400

出　　处：《动力学与控制学报》2020年第1期69-75,共7页Journal of Dynamics and Control

基　　金：国家自然科学基金资助项目(No.11872003);北方工业大学“毓杰团队培养计划”资助项目(No.107051360019XN137/002)~~

摘　　要：本文以前包钦格复合体中两个耦合神经元为研究对象,并考虑钙离子动力学的神经元动力学模型。利用相平面分析、分岔分析和快慢动力学分析等方法,研究钙离子动力学和控制钙激活的非特异性阳离子电流的电导对前包钦格复合体的放电模式的影响,并从动力学的角度解释了其放电活动产生及其转迁的机制。结果表明钙离子的周期性波动和非特异性阳离子电流都会影响簇放电的类型,钙离子的周期性波动是产生复杂簇放电的关键因素。In this paper,we study the dynamics of two-coupled pre-Botzinger complex with calcium ion current.By phase-analysis,bifurcation and fast-slow decomposition,we investigate the effects of the intracellular Ca^2+concentration and the calcium-activated nonspecific cationic current(ICAN)on the firing activities of pre-Botzinger complex,and explain the generation and transition of the bursting activities.The results show both the periodic oscillation of Ca2+concentration and dynamics of ICAN will decide the types of firing activities,and the periodic oscillation of Ca2+concentration is the key factor of complex bursting.

关 键 词：前包钦格复合体 族放电 分岔 快慢分析 

分 类 号：Q424[生物学—神经生物学]