CSMD1基因多态性与精神分裂症认知功能关系的研究进展  

Research progress of CSMD1 gene polymorphism and cognitive function in schizophrenia

作　　者：袭琢 刘薇[1] Xi Zhuo;Liu Wei(Mental Health Center,the First Affiliated Hospital of Harbin Medical University,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第一医院精神卫生中心,150001

出　　处：《神经疾病与精神卫生》2019年第10期977-979,共3页Journal of Neuroscience and Mental Health

摘　　要：精神分裂症是一种严重的精神疾病,大多数患者伴有认知功能的缺陷,给患者、家庭和社会造成了相当大的负担。精神分裂症的遗传率较高。在过去的十年中,发现许多与精神分裂症有关的基因变异,从而使人们更好地理解其遗传结构的复杂性。最近的研究还表明,部分与精神分裂症有关的基因变异会影响认知能力。进一步研究这些基因对认知功能的影响将有助于了解遗传因素对精神分裂症认知功能障碍的作用。本综述旨在探讨CSMD1(CUB and SUSHI multiple domains-1)基因多态性与精神分裂症及其认知功能损害关系的研究进展。Schizophrenia is a serious mental illness,most of them are accompanied by cognitive impairment,which places a great burden on patients,families and society.Schizophrenia has a high heritable rate.In the past decade,many genetic variants associated with schizophrenia have been discovered,leading to a better understanding of the complexity of its genetic structure.Recent studies have also shown that genetic variants associated with schizophrenia affect cognitive ability.Further study on the effect of these genes on cognitive function will help us to understand the effect of genetic factors on cognitive dysfunction in schizophrenia.The purpose of this study was to investigate the relationship between CUB and SUSHI multiple domains-1(CSMD1)gene polymorphism and schizophrenia and its cognitive impairment.

关 键 词：多态性 单核苷酸 精神分裂症 认知损害 CSMD1基因 综述 

分 类 号：R74[医药卫生—神经病学与精神病学]