循环miRNA作为癫痫诊断潜在生物标志物的研究进展  

Research progress of circulating miRNA as potential biomarker for epilepsy diagnosis

作　　者：赵海燕 黄颖[1] 李永男[1] Zhao Haiyan;Huang Ying;Li Yongnan(Department of Neurology,the Fourth Affiliated Hospital of Harbin Medical University,Heilongjiang Province,Harbin 150001,China)

机构地区：[1]哈尔滨医科大学附属第四医院神经内科

出　　处：《疑难病杂志》2020年第3期307-310,共4页Chinese Journal of Difficult and Complicated Cases

基　　金：黑龙江省卫生计生委科研课题(2018128);哈尔滨医科大学附属第四医院特别资助项目(HYDSYTB201910)~~

摘　　要：癫痫是一种常见的慢性神经系统疾病,由于其病因及临床表现的复杂性和异质性,成为最难诊疗的疾病之一。近年来,随着分子生物学技术的发展,在癫痫患者和癫痫动物模型中发现差异性表达的miRNAs,并且可以在循环中检测到miRNAs的表达变化,这为癫痫的精准诊治提供了新的思路和方向。文章总结了癫痫患者或癫痫动物模型中差异性表达的循环miRNAs,并对可能作为癫痫诊断潜在生物标志物和治疗靶点进行综述。Epilepsy is a common chronic nervous system disease.Because of the complexity and heterogeneity of its etiology and clinical manifestations,it has become one of the most difficult diseases to diagnose and treat.In recent years,with the development of molecular biology technology,miRNAs with different expression are found in epilepsy patients and animal models,and the expression changes of miRNAs can be detected in the circulation,which provides a new idea and direction for the accurate diagnosis and treatment of epilepsy.This paper summarizes the circulating miRNAs differentially expressed in epileptic patients or animal models,and reviews the potential biomarkers and therapeutic targets for epilepsy diagnosis.

关 键 词：微小RNA 癫痫 诊断 生物标志物 

分 类 号：R742.1[医药卫生—神经病学与精神病学]