miR-155在MALT淋巴瘤组织中的表达及其与预后的关系  

Expression of miR-155 in MALT lymphoma tissues and its relationship with prognosis

作　　者：李丽[1] 杨一飞[2] 杨俊超[1] 李卫敏 毛丹 史晓雪 Li Li;Yang Yifei;Yang Junchao;Li Weimin;Mao Dan;Shi Xiaoxue(Department of Hematology,Affiliated Hospital of Hebei University of Engineering,Hebei Handan 056000,China;Department of Discipline Construction and Graduate Education,Affiliated Hospital(School of Clinical Medicine),Hebei University of Engineering,Hebei Handan 056000,China)

机构地区：[1]河北工程大学附属医院血液内科,河北邯郸056000 [2]河北工程大学附属医院(临床医学院)学科建设与研究生教育办公室,河北邯郸056000

出　　处：《现代肿瘤医学》2020年第5期806-809,共4页Journal of Modern Oncology

基　　金：河北省重点研发计划健康医疗与生物医药专项项目(编号:18277782D);邯郸市科学技术研究与发展计划项目(编号:1723208068-2)

摘　　要：目的:探讨miR-155在MALT淋巴瘤组织中的表达及其与预后的关系。方法:收集2007年3月至2014年3月首次就诊于河北工程大学附属医院的36例均经病理证实为MALT淋巴瘤患者的带瘤组织和瘤旁组织(距瘤>2 cm),qPCR法检测MALT淋巴瘤患者瘤组织和瘤旁组织中miR-155表达水平,入选患者均给予标准CHOP方案化疗治疗8个周期,根据实体瘤疗效评价标准,将患者分为有效组和无效组,对比观察两组患者血清中miR-155表达水平;通过门诊或打电话方式对患者进行随访,以miR-155表达水平的平均值为阈值将治疗后患者分为miR-155高表达组(23例)和miR-155低表达组(13例),对比观察两组患者3年生存率。结果:36例MALT淋巴瘤患者瘤组织和瘤旁组织中miR-155表达水平分别为6.63±0.70、1.29±0.05,两者差异具有统计学意义(P<0.05);CHOP方案治疗8个周期后,有效组和无效组患者血清中miR-155表达水平分别为2.21±0.14、7.01±0.54;随访发现,治疗后miR-155高表达组和miR-155低表达组患者3年生存率分别为56.5%和76.9%,以上差异均具有统计学意义(P<0.05)。结论:miR-155表达水平可能与MALT淋巴瘤发生发展及预后有关。Objective:To investigate the expression of miR-155 in MALT lymphoma and its relationship with prognosis.Methods:From 2007.03 to 2014.03,a total of 36 patients with MALT lymphoma who were first diagnosed in Department of Hematology of the Affiliated Hospital of Hebei University of Engineering tissues and paraneoplastic tissue(from tumor>2 cm)were collected.Using qPCR methods to detect the expression of miR-155 in tumor tissues and paraneoplastic tissues of patients with MALT lymphoma,then 36 patients were given CHOP regimen treatment for 8 cycles.According to the evaluation criteria of solid tumor efficacy,the patients were divided into active group and inactive group.Serum levels of miR-155 in two groups of patients were compared,and patients were followed-up by clinic or by phone.According to the threshold of the average value of miR-155 expression level,the patients were divided into miR-155 high expression group(23 patients)and miR-155 low expression group(13 patients).The three-year survival rate of the two groups of patients was compared.Results:The expression levels of miR-155 in tumor tissues and paraneoplastic tissues respectively were 6.63±0.70 and 1.29±0.05,and the differences was statistically significant(P<0.05).After 8 cycles of CHOP treatment,the serum levels of miR-155 in the effective and ineffective groups respectively were 2.21±0.14 and 7.01±0.54.The follow-up showed that after treatment the three-year survival rates of patients with miR-155 high expression group and miR-155 low expression group respectively were 56.5%and 76.9%,and the differences was statistically significant(P<0.05).Conclusion:The expression level of miR-155 may be related to the development and prognosis of MALT lymphoma.

关 键 词：MIR-155 MALT淋巴瘤 预后 

分 类 号：R733.4[医药卫生—肿瘤]