Sirt4与恶性肿瘤的相关研究进展  

Research progresses between Sirt4 and malignant neoplasms

作　　者：王常明 朱育焱[1] 李士杰 孔垂泽[1] Wang Changming;Zhu Yuyan;Li Shijie;Kong Chuize(Department of Urology,the First Affiliated Hospital of China Medical University,Liaoning Shenyang 110001,China;Department of Pediatrics,the First Affiliated Hospital of China Medical University,Liaoning Shenyang 110001,China)

机构地区：[1]中国医科大学附属第一医院泌尿外科,辽宁沈阳110001 [2]中国医科大学附属第一医院儿科,辽宁沈阳110001

出　　处：《现代肿瘤医学》2020年第5期835-838,共4页Journal of Modern Oncology

基　　金：国家自然科学基金资助项目(编号:81672523)

摘　　要：谷氨酰胺分解代谢能够提供能量和代谢中间物来维持线粒体功能和细胞大分子合成,这对许多肿瘤细胞的生长和增殖起着关键作用。沉默信息调节因子2-4(Sirt4)是七种哺乳动物Sirtuins之一,主要位于细胞线粒体中并可以调节许多重要的生物过程,如应激抵抗、维持基因组稳定性、能量代谢和衰老等。近年来,众多报道指出Sirt4通过调节谷氨酰胺分解代谢发挥着肿瘤抑制的作用。本文就近些年有关Sirt4与恶性肿瘤相关的研究进行总结和概述。Glutamine catabolism plays an critical role for growth and proliferation of many cancer cells by providing energy and metabolites for the maintenance of mitochondrial functions and macromolecular synthesis.Silent information regulator two 4(Sirt4)is one of the seven mammalian sirtuins and located in the cellular mitochondria which can regulate many important biological processes,such as stress resistance,genome stability,energy metabolism and aging.In recent years,Sirt4 has been reported to function as a tumor suppressor by regulating glutamine catabolism.In this study,research progresses in the field of Sirt4 and malignant neoplasms are reviewed in the last few years.

关 键 词：Sirt4 肿瘤抑制因子 代谢重编程 恶性肿瘤 

分 类 号：R730.5[医药卫生—肿瘤]