血清Orexin A、ALB、Leptin水平用于胃肠道肿瘤营养不良预测的临床价值  

Clinical value of serum Orexin A,ALB and Leptin levels in predicting malnutrition in gastrointestinal tumors

作　　者：孙江华[1] 秦晓辉[1] 刘昱良 Sun Jianghua;Qin Xiaohui;Liu Yuliang(General Surgery Department,the First Hospital of Handan City,Hebei Handan 056001,China)

机构地区：[1]邯郸市第一医院普外科

出　　处：《现代肿瘤医学》2020年第6期976-980,共5页Journal of Modern Oncology

基　　金：邯郸市科学技术研究与发展计划项目(编号:1323108137)

摘　　要：目的:探析血清中细胞因子Orexin A、ALB、Leptin水平与胃肠道肿瘤营养不良的相关性,为临床营养状况评估提供依据。方法:回顾性分析2016年3月至2017年12月间在本院住院治疗的124例胃肠道肿瘤患者的诊疗数据,采用PG-SGA评分系统对患者营养状况进行评估,并对其血清中Orexin A、ALB、Leptin、TNF-α等细胞因子水平进行生化检测,采用Logistic回归方法分析胃肠道肿瘤营养中相关因素。结果:根据PG-SGA评分,A级(营养状况良好)患者43例,B级(中度或可疑营养不良)患者59例,C级(重度营养不良)患者22例。营养不良患者所占比例65.32%。单因素分析中,患者年龄、血清中Orexin A、ALB、TNF-α和Leptin水平与营养状态有关(P<0.05)。Logistic回归分析得出患者血清中Orexin A(OR=1.075,95%CI:1.025~1.126)、ALB(OR=0.932,95%CI:0.681~1.276)、Leptin(OR=2.077,95%CI:2.009~2.148)的含量与营养状况有相关性。ROC曲线分析显示Orexin A(AUG=0.708)、ALB(AUG=0.791)、Leptin(AUG=0.592)水平均可用于胃肠道肿瘤患者营养不良的预测,且可用作联合诊断。结论:血清中Orexin A、ALB、Leptin水平与胃肠道肿瘤营养不良相关,可用于临床营养不良的预测。Objective:To analyze the correlation between serum levels of cytokines Orexin A,ALB and Leptin and gastrointestinal tumor malnutrition,and to provide evidence for clinical nutritional status assessment.Methods:A retrospective analysis of 124 patients with gastrointestinal tumors who were hospitalized in our hospital from March 2016 to December 2017 was performed.The PG-SGA scoring system was used to evaluate the nutritional status of patients and their serum.The levels of cytokines such as Orexin A,ALB,Leptin and TNF-αwere detected by biochemical tests.Logistic regression was used to analyze the related factors of gastrointestinal tumor nutrition.Results:According to the PG-SGA score,43 patients with grade A(good nutritional status),59 patients with grade B(moderate or suspected malnutrition),and 22 patients with grade C(severe malnutrition).The proportion of malnourished patients was 65.32%.In the univariate analysis,the age of patients,serum levels of Orexin A,ALB,TNF-αand Leptin were related to nutritional status(P<0.05).Logistic regression analysis showed that patients had serum Orexin A(OR=1.075,95%CI:1.025~1.126),ALB(OR=0.932,95%CI:0.681~1.276),Leptin(OR=2.077,95%CI:2.009~2.148).The content of was related to the nutritional status.ROC curve analysis showed that Orexin A(AUG=0.708),ALB(AUG=0.791)and Leptin(AUG=0.592)levels were all predictive of malnutrition in patients with gastrointestinal cancer and could be used as a joint diagnosis.Conclusion:Serum levels of Orexin A,ALB and Leptin are associated with gastrointestinal tumor malnutrition and can be used for the prediction of clinical malnutrition.

关 键 词：细胞因子 胃肠道肿瘤 营养不良 预测 

分 类 号：R735.2[医药卫生—肿瘤] R735.3[医药卫生—临床医学]