系统炎症反应联合肿瘤免疫评分对结直肠癌肝转移患者术后预后的预测价值  

Prognostic value of systemic inflammatory response combined with tumor immunological score in patients with liver metastases from colorectal cancer

作　　者：宋钰[1] 张琳[1] 王光辉[1] 陈明[2] Song Yu;Zhang Lin;Wang Guanghui;Chen Ming(General Surgery,First Affiliated Hospital of Xi'an Jiaotong University,Shaanxi Xi'an 710061,China;Department of Hepatobiliary Surgery,Shengjing Hospital Affiliated to China Medical University,Liaoning Shenyang 110004,China)

机构地区：[1]西安交通大学第一附属医院普通外科,陕西西安710061 [2]中国医科大学附属盛京医院肝胆外科,辽宁沈阳110004

出　　处：《现代肿瘤医学》2020年第6期984-988,共5页Journal of Modern Oncology

基　　金：陕西省社会发展科技攻关项目(编号:2015SF057)

摘　　要：目的:分析系统炎症反应联合肿瘤免疫评分对结直肠癌肝转移患者预后的预测价值。方法:将2014年1月至2016年1月期间因结直肠癌肝转移于我院进行治疗的105例患者作为研究对象,所有患者术后均进行为期3年的跟踪随访。分别采用系统炎症反应评分与肿瘤免疫评分对患者术后预后情况进行评价,评价系统炎症反应联合肿瘤免疫评分对结直肠癌肝转移患者预后的预测价值。结果:mGPS评分下,0分组术后3年总生存率高于1分组与2分组(P<0.05)。原发灶免疫评分下,5组患者术后3年总生存率呈现由低评分至高评分逐渐升高的趋势(P<0.05)。LM免疫评分下5组患者术后3年总生存率对比无明显差异(P>0.05)。联合评分下,高危组患者术后3年总生存率明显低于低危组(35.2%vs 84.3%)(P<0.05)。系统炎症反应联合肿瘤免疫评分对CRLM术后OS的预测价值较高,当截断值为1.8时,AUC为0.796,灵敏度为73.94%,特异度为87.56%。结论:临床针对CRLM患者手术治疗后预后情况的预测使用系统炎症反应联合肿瘤免疫评分效果较好,对患者后续治疗方案的制定及改善提供了数据支持,值得临床应用。Objective:To analyze the prognostic value of systemic inflammatory response combined with tumor immune score in patients with liver metastasis of colorectal cancer.Methods:From January 2014 to January 2016,105 patients treated in our hospital for colorectal cancer liver metastasis disease were selected as research objects.All patients were followed up for 3 years after surgery.Systematic inflammatory response score and tumor immune score were used to evaluate the postoperative prognosis of patients,and to evaluate the prognostic value of systematic inflammatory response combined with tumor immune score in patients with liver metastasis of colorectal cancer.Results:Under the mGPS score,the 3-year overall survival rate of group 0 was higher than that of group 1 and group 2(P<0.05).With respect to the immune score of the primary lesion,the 3-year overall survival rate of the 5 groups presented a gradually increasing trend from low score to high score(P<0.05).There was no significant difference in overall survival rate at 3 years after operation in the 5 groups under LM immune score(P>0.05).Under combined scores,the 3-year overall survival rate of high-risk group was significantly lower than that of low-risk group(35.2%vs 84.3%)(P<0.05).The predictive value of systemic inflammatory response combined with tumor immune score for OS after CRLM surgery was relatively high.When the cut-off value was 1.8,the AUC was 0.796,the sensitivity was 73.94%,and the specificity was 87.56%.Conclusion:Systemic inflammatory response combined with tumor immunological score is more accurate in the postoperative outcome of patients with liver metastases from colorectal cancer,and the predictive value is higher.It provides scientific and favorable data support for the development and improvement of follow-up treatment plan,and the clinical application value is significant.

关 键 词：系统炎症反应 肿瘤免疫评分 结直肠癌 肝转移 

分 类 号：R735[医药卫生—肿瘤]