良性多囊性腹膜间皮瘤1例及文献复习  

Benign multicystic peritoneal mesothelioma:A case report and review of the literature

作　　者：史冠军 王冰 卢一艳[2] 夏奥 许洪斌[1] Shi Guanjun;Wang Bing;Lu Yiyan;Xia Ao;Xu Hongbin(Departmet of Myxoma,Aerospace Center Hospital,Beijing 100041,China;Department of Pathology,Aerospace Center Hospital,Beijing 100041,China)

机构地区：[1]航天中心医院黏液瘤科,北京100041 [2]航天中心医院病理科,北京100041

出　　处：《现代肿瘤医学》2020年第6期997-1000,共4页Journal of Modern Oncology

基　　金：航天中心医院科研基金项目(编号:YN201909)

摘　　要：目的:探讨良性多囊性腹膜间皮瘤(benign multicystic peritoneal mesothelioma,BMPM)临床病理特征、诊断及治疗,提高对该病的认识。方法:回顾性分析我院2019年1月收治的1例BMPM患者的临床资料并复习相关文献。结果:该例患者女性,48岁,主因“反复右下腹疼痛5个月”入院,在全麻下行腹腔镜检查+中转开腹:肿瘤细胞减灭术+腹腔热灌注化疗(cytoreducrive surgery+hyperthermic intraperitoneal chemotherapy,CRS+HIPEC)。术后病理报告示:良性囊性腹膜间皮瘤,免疫组化结果:Calretinin(+),MC(+),WT-1(+),CK(+),Vimentin(+),CK5/6(+),CEA(-),CK7(+),CK20(-),PAX-8(+),ER(-),PR(-)。结论:BMPM临床发病率较低,无典型临床表现且缺乏特异性检查,术前诊断较困难,确诊依靠术后病理及免疫组化结果。CRS+HIPEC是目前首选有效的治疗方法,预后良好,复发率较高但恶变率低。Objective:To investigate the clinicopathological features,diagnosis and treatment of benign polycystic peritoneal mesothelioma(BMPM)and to improve the understanding of the disease.Methods:The clinical data of a BMPM patient admitted to our hospital in January 2019 were retrospectively analyzed and relevant literatures were reviewed.Results:The 48-year-old female patient was admitted from the main cause of"repeated right lower abdomen pain for five months".An exploratory laparotomy under general anesthesia was performed:Cytoreducrive surgery+hyperthermic intraperitoneal chemotherapy(CRS+HIPEC).Postoperative pathological report showed:Cystic peritoneal mesothelioma.Immunohistochemical results showed Calretinin(+),MC(+),WT-1(+),CK(+),Vimentin(+),CK5/6(+),CEA(-),CK7(+),CK20(-),PAX-8(+),ER(-),PR(-).Conclusion:BMPM has a low clinical incidence,no typical clinical manifestations and lack of specific examination.Preoperative diagnosis is difficult,and the diagnosis depends on postoperative pathological and immunohistochemical results.CRS+HIPEC is the first choice of effective treatment at present,with good prognosis,low malignant transformation rate but high recurrence rate.

关 键 词：良性多囊性腹膜间皮瘤 肿瘤细胞减灭术 腹腔热灌注化疗 

分 类 号：R735.5[医药卫生—肿瘤]