观察隐匿性黄斑营养不良患者黄斑神经节细胞复合体厚度  

Research on macular ganglion cell complex thickness of occult macular dystrophy

作　　者：田军[1] Tian Jun(Department of opthalmology,Zhengzhou Second People’s hospitial,Zhengzhou Ophthalmological Hospital,Zhengzhou 450000,China)

机构地区：[1]郑州市第二人民医院眼科郑州市眼科医院

出　　处：《中国斜视与小儿眼科杂志》2019年第4期34-34,I0003,I0004,共3页Chinese Journal of Strabismus & Pediatric Ophthalmology

摘　　要：目的观察隐匿性黄斑营养不良患者黄斑神经节细胞复合体厚度。方法回顾性分析我院2010年3月至2017年3月门诊就诊的9例(9眼)隐匿性黄斑营养不良患者的病例资料。患者为A组,年龄21~44岁,平均(30.2±8.3)岁;选择9例(9眼)同期正常人作为B组,正常对照组。所有受试者均进行裸眼视力、显然验光、裂隙灯、眼底照相、荧光素血管造影、视网膜电图、多焦视网膜电图、光学相干断层扫描检测黄斑区视网膜神经节细胞复合体(GCC)厚度等检查。比较两组GCC不同区域的厚度,分析A组患者最佳矫正视力与GCC厚度之间的相关性。结果 A组患者GCC总体、上方、下方厚度均较B组降低,差异有统计学意义(P<0.05)。A组患者最佳矫正视力与GCC总体厚度无相关性(r=0.009,P=0.971),与GCC上方厚度无相关性(r=0.461,P=0.054),与GCC下方厚度无相关性(r=0.059,P=0.816)。结论隐匿性黄斑营养不良患者GCC不同区域厚度均降低。光学相干断层扫描作为一种非侵入性的临床检查,可靠安全,GCC厚度检查有可能成为临床上诊断OMD的辅助手段之一,并可作为OMD治疗效果的评测方法。Objective To observe the macular ganglion cell complex(GCC) thickness in patients with occult macular dystrophy(OMD).Methods Retrospective analysis of 9 cases(9 eyes) with OMD in our hospital from March 2010 to March 2017 was made for the study.The patients were in group A,with a mean age of 30.2±8.3 years old(range,21~44 years old);The normal control group(group B) included 9 homologous normal patients(9 eyes).All subjects underwent a comprehensive standard ophthalmic examination,including best corrected visual acuity,optometry,slit-lamp biomicroscopy,fundus photography,fundus fluorescein angiography,electroretinogram,multifocal electroretinogram,and optical coherence tomography to examine the GCC thickness.The different regions of GCC thickness in the two groups were compared.And whether the best corrected visual acuity was correlated with GCC thickness in group A was observed.Results The different regions of GCC thickness in group A were lower than that in group B(P<0.05).There was no correlation between the best corrected visual acuity and the overall GCC thickness(r=0.009,P=0.971).Meanwhile,no correlation was found between the best corrected visual acuity and the superior GCC thickness(r=0.461,P=0.054),and the inferior GCC thickness(r=0.059,P=0.816).Conclusion The different regions of GCC thickness in patients with OMD are reduced.Optical coherence tomography,as a non-invasive clinical examination,is reliable and safe.GCC thickness examination may be an auxiliary approach in diagnosis of OMD,and an evaluation method during treatment of OMD in clinical.

关 键 词：隐匿性黄斑营养不良 黄斑区视网膜神经节细胞复合体厚度 光学相干断层扫描 

分 类 号：R774.5[医药卫生—眼科]