温肾化痰祛瘀法辅助米非司酮治疗子宫肌瘤肾虚血瘀证患者临床效果  

Effect of Wenshen huatan qieyu combined mifepristone for treating women with uterine myoma because of renal deficiency and blood stasis

作　　者：王随英 杨静 张从沛 WANG Suiying;YANG Jing;ZHANG Congpei(Shangqiu Traditional Chinese Medicine Hospital,Henan Province,47600;The First Affiliated Hospital of Zhengzhou University)

机构地区：[1]河南省商丘市中医院,476000 [2]郑州大学第一附属医院

出　　处：《中国计划生育学杂志》2020年第2期172-175,共4页Chinese Journal of Family Planning

摘　　要：目的:探究温肾化痰祛瘀法辅助米非司酮治疗子宫肌瘤肾虚血瘀证,对患者子宫三径、肌瘤体积及雌激素硫酸转移酶(SULT1E1)、激素水平影响。方法:选取本院2015年12月-2019年4月收治的子宫肌瘤患者98例分为两组。对照组给予单用米非司酮治疗,观察组米非司酮加用温肾化痰祛瘀法治疗,分析临床疗效。结果:治疗后观察组子宫三径(93.0±10.1mm 3)、子宫肌瘤体积(28.1±6.2mm 3)均小于对照组,血红蛋白(128.36±10.01g/L)水平高于对照组,子宫内膜组织SULT1E1含量(28.02±3.55%)及血清孕酮(10.14±2.85μg/L)、促卵泡刺激素(20.11±3.12U/L)、雌二醇(155.21±29.89pmol/L)、高敏-C反应蛋白(1.39±0.79mg/L)、血管内皮生长因子(132.65±26.75ng/L)均低于对照组(均P<0.05)。结论:辅助温肾化痰祛瘀法可更好改善子宫肌瘤患者性激素水平,降低SULT1E1、高敏-C反应蛋白、血管内皮生长因子水平,缩小子宫三径和子宫肌瘤。Objective:To explore the effect of Wenshen huatan qieyu combined mifepristone for treating women with uterine myoma because of renal deficiency and blood stasis,and to study its influence on the value of the uterine three diameters,the volume of the myoma,and the level of estrogen sulfate transferase in endometrial tissue,and sex hormones levels of the women.Methods:98 women with uterine myoma because of renal deficiency and blood stasis were divided into two groups from December 2015-April 2019.The women in the control group were treated by mifepristone alone,and the women in the observation group were treated by Wensen huatan qieyu combined mifepristone.The clinical effect of women in the two groups was analyzed.Results:After treatment,the value of uterine third diameter,uterine myoma volume,the level of estrogen sulfate transferase in endometrial tissue,and levels of serum progesterone(P),follicle-stimulating mature hormone(FSH),estradiol(E 2),highly sensitive-C reactive protein(hs-CRP),and vascular endothelial growth factor(VEGF)of women in the observation group were 93.0±10.1mm 3,28.1±6.2mm 3,28.02±3.55%,10.14±2.85μg/L,20.11±3.12U/L,155.21±29.89pmol/L,1.39±0.79mg/L,and 132.65±26.75ng/L,respectively,which were significant less than those of women in the control group(P<0.05).The hemoglobin(Hb)level of women in the observation group was 128.36±10.01g/L,which was significant higher than that of women in the control group(P<0.05).Conclusion:Wensen huatan qieyu can improve the levels of sex hormones of women with uterine fibroids,reduce the level of estrogen sulfate transferase in endometrial tissue,decrease the levels of serum hs-CRP and VEGF,and can reduce the value of three diameters and volume of uterine fibroids.

关 键 词：子宫肌瘤 温肾化痰祛瘀法 肾虚血瘀 子宫径线 性激素 雌激素硫酸转移酶 

分 类 号：R737.33[医药卫生—肿瘤]