Matriptase及HAI-1在子宫内膜癌中的表达及临床意义  

The expression and clinical significance of Matriptase and HAI-1 in endometrial carcinoma tissue

作　　者：熊丽丽 薛秀珍 段丽艳 蔡晓磊 XIONG Lili;XUE Xiuzhen;DUAN Liyan;CAI Xiaolei(The First Affiliated Hospital of Henan University of Science and Technology,Luoyang,Henan Province,471000)

机构地区：[1]河南科技大学第一附属医院

出　　处：《中国计划生育学杂志》2020年第2期208-212,共5页Chinese Journal of Family Planning

摘　　要：目的:探讨丝氨酸蛋白酶(Matriptase)及肝细胞生长因子活化因子抑制剂(HAI-1)在子宫内膜癌中的表达及临床意义。方法:应用免疫组织化学方法检测Matriptase及HAI-1在正常子宫内膜、不典型增生以及子宫内膜癌组织中的表达,分析其阳性表达率与临床病理特征的关系,探讨Matriptase与HAI-1表达相关性。结果:Matriptase表达阳性率子宫内膜癌>不典型增生>正常子宫内膜,HAI-1表达阳性率子宫内膜癌<不典型增生<正常子宫内膜(P均<0.05),子宫内膜癌组Matriptase表达(+++)所占比例高于正常子宫内膜组和不典型增生组(P<0.001),子宫内膜癌组HAI-1表达(+++)所占比例低于正常子宫内膜组和不典型增生组(P<0.001),不典型增生组HAI-1表达(+++)的比例低于正常子宫内膜组(P<0.05);与组织高分化、无淋巴结转移及临床分期I-II期组织比较,组织低分化、有淋巴结转移及临床分期Ⅲ-Ⅳ期的Matriptase阳性率明显升高,HAI-1阳性率明显降低(P<0.05),其中临床分期I期与II期之间、Ⅲ期与Ⅳ期之间Matriptase及HAI-1阳性率均无差异(P>0.05),Matriptase及HAI-1的阳性率在患者年龄<50岁与≥50岁之间,以及腺癌与其他病理类型之间均无差异(P>0.05),子宫内膜癌组织中Matriptase与HAI-1的表达呈负相关(r=-0.485,P=0.008)。结论:Matriptase高表达及HAI-1低表达与子宫内膜癌的发生、发展有关,可能作为子宫内膜癌的治疗靶点和预后标志物。Objective:To explore the expression and clinical significance of Matriptase and HAI-1 in endometrial carcinoma tissue.Methods:The expression of Matriptase and HAI-1 in normal endometrium tissue,atypical hyperplasia tissue,and endometrial carcinoma tissue were detected by immunohistochemistry.The relationship between the positive expression rate of Matriptase and HAI-1 and clinicopathological features was analyzed.The correlation between Matriptase and HAI-1 expression in endometrial carcinoma was analyzed.Results:The positive expression rate of Matriptase in normal endometrium tissue was lowest,and that in endometrial cancer tissue was highest(P<0.05).The positive expression rate of HAI-1 in normal endometrium tissue was highest,and that in endometrial cancer tissue was lowest(P<0.05).The percentage of Matriptase expression(+++)in endometrial cancer tissue was significant higher than that in normal endometrium tissue and atypical hyperplasia tissue(P<0.001),and the percentage of HAI-1 expression(+++)in endometrial cancer tissue was significant lower than that in normal endometrium tissue and atypical hyperplasia tissue(P<0.001).The proportion of HAI-1 expression(+++)in the dysplasia tissue was significant lower than that in the normal endometrium tissue(P<0.05).Compared with that tissue with hyperdifferentiation,lymph node metastasis and clinical stage I–II,Matriptase positive rate has increased significantly,HAI-1 positive rate had decreased significantly in tissue with hypodifferentiation,lymph node metastasis,and clinical stageⅢ-Ⅳ(P<0.05).Matriptase and HAI-1 positive rate had no statistical difference in tissue between clinical stage I and II,and between clinical stageⅢandⅣ(P>0.05).There was no significant different in the Matriptase and HAI-1 positive rate between patients aged<50 years old and patients aged equal to or more than 50 years old,and between patients with adenocarcinoma and patients with other type of pathological carcinoma(P>0.05).In endometrial cancer issue,the Matriptase positive ex

关 键 词：子宫内膜癌 子宫内膜不典型增生 丝氨酸蛋白酶 肝细胞生长因子活化因子抑制剂 

分 类 号：R737.33[医药卫生—肿瘤]