宫颈鳞状细胞癌组织中细胞外信号调节激酶1/2、p-细胞外信号调节激酶1/2的表达在新辅助化疗疗效预测中的价值  

Value of extracellular signal-regulated kinase 1/2 and p-extracellular signal-regulated kinase 1/2 expression in predicting the efficacy of neoadjuvant chemotherapy in cervical squamous cell carcinoma

作　　者：龚懂文 罗纯[1] 范刚[1] Gong Dongwen;Luo Chun;Fan Gang(Department of Gynecology,Bazhong Central Hospital of Sichuan Province,Sichuan Bazhong 636000,China)

机构地区：[1]四川省巴中市中心医院妇科,636000

出　　处：《中国医师进修杂志》2020年第1期16-20,共5页Chinese Journal of Postgraduates of Medicine

摘　　要：目的探讨宫颈鳞状细胞癌组织中细胞外信号调节激酶(ERK)1/2、p-ERK 1/2的表达在新辅助化疗疗效预测中的价值。方法选取2016年5月至2018年5月四川省巴中市中心医院就诊的57例患宫颈鳞状细胞癌并行新辅助化疗患者,统计分析治疗期间不良反应发生情况;比较宫颈鳞状细胞癌组织治疗前后ERK 1/2、p-ERK 1/2表达变化情况,分析ERK 1/2、p-ERK 1/2表达水平与新辅助化疗有效率的关联。结果治疗后有效率为68.42%(39/57),不良反应发生率为24.56%(14/57);治疗前ERK1/2阳性率为87.72%(50/57),治疗后ERK 1/2阳性率为31.58%(18/57),差异有统计学意义(P<0.01);治疗前p-ERK 1/2阳性率为75.44%(43/57),治疗后p-ERK 1/2阳性率为19.30%(11/57),差异有统计学意义(P<0.01);治疗前ERK 1/2阳性组治疗后有效率为53.12%(17/32),治疗前ERK 1/2阴性组治疗后有效率为88.00%(22/25),两者比较差异有统计学意义(P<0.05)。治疗前p-ERK 1/2阳性组治疗后有效率为60.47%(26/43),治疗前p-ERK 1/2阴性组治疗后有效率为13/14,两者比较差异有统计学意义(P<0.05)。结论宫颈鳞状细胞癌组织中ERK 1/2、p-ERK 1/2能预测新辅助化疗疗效。Objective To explore the value of extracellular signal-regulated kinase(ERK)-1/2 and p-ERK-1/2 expression in predicting the efficacy of neoadjuvant chemotherapy in cervical squamous cell carcinoma.Methods Fifty-seven patients with cervical squamous cell carcinoma who received neoadjuvant chemotherapy from May 2016 to May 2018 in Bazhong Central Hospital of Sichuan Province were selected.The incidence of adverse reactions during treatment was analyzed.The expression of ERK 1/2 and p-ERK 1/2 in cervical squamous cell carcinoma tissues before and after treatment was compared,and the expression levels of ERK 1/2 and p-ERK 1/2 and the effectiveness of neoadjuvant chemotherapy were analyzed.Results After treatment,the effective rate was 68.42%(39/57),and the incidence of adverse reactions was 24.56%(14/57).Before treatment,the positive rate of ERK1/2 was 87.72%(50/57),after treatment,the positive rate of ERK 1/2 was 31.58%(18/57),and there were statistical differences(P<0.01).Before treatment,the positive rate of p-ERK 1/2 was 75.44%(43/57),after treatment,the positive rate of p-ERK 1/2 was 19.30%(11/57),and there was statistical difference(P<0.01).The effective rate after treatment in pre-treatment ERK 1/2 positive group was significantly lower than that in pre-treatment ERK 1/2 negative group:53.12%(17/32)vs.88.00%(22/25),and there was statistical difference(P<0.05).The effective rate after treatment in pre-treatment p-ERK 1/2 positive group was significantly lower than that in pre-treatment p-ERK 1/2 negative group:60.47%(26/43)vs.13/14,and there was statistical difference(P<0.05).Conclusions ERK 1/2 and p-ERK 1/2 in cervical squamous cell carcinoma can predict the efficacy of neoadjuvant chemotherapy.

关 键 词：宫颈肿瘤 癌 鳞状细胞 细胞外信号调节激酶1/2 p-细胞外信号调节激酶1/2 新辅助化疗 

分 类 号：R737[医药卫生—肿瘤]