应用CANTAB测评注意缺陷多动障碍儿童执行功能缺陷  

Assessment of executive function deficit through use of the CANTAB in children with attention-deficit/hyperactivity disorder

作　　者：袁靖 裴栩瑶 范自立 孙霄 王鹏[1] 敦玥 杨莉[1] 曹庆久[1] 王玉凤[1] YUAN Jing;PEI Xuyao;FAN Zili;SUN Xiao;WANG Peng;DUN Yue;YANG Li;CAO Qingjiu;WANG Yufeng(Peking University Sixth Hospital,Peking University Institute of Mental Health,NHC Key Laboratory of Mental Health(Peking University),National Clinical Research Center for Mental Disorders(Peking University Sixth Hospital)Peking University Sixth Hospital,Beijing 100083,China)

机构地区：[1]北京大学第六医院,北京大学精神卫生研究所,国家卫生健康委员会精神卫生学重点实验室(北京大学),国家精神心理疾病临床医学研究中心(北京大学第六医院),北京100083

出　　处：《中国心理卫生杂志》2020年第3期201-205,共5页Chinese Mental Health Journal

基　　金：国家重点研发计划(2016YFC1306103);国家自然科学基金(81873804,81471382);认知神经科学与学习国家重点实验室开放课题基金(CNLYB1508);北京大学医学部-英国伦敦国王学院医学研究联合研究所基金(BMU20170624)。

摘　　要：目的:探讨应用剑桥神经心理自动化成套测试软件(CANTAB)测评注意缺陷多动障碍(ADHD)儿童执行功能缺陷的可行性。方法:选取符合DSM-IVADHD诊断标准的6~16岁儿童71例及28例年龄、性别、智商匹配的正常对照,应用CANTAB评估ADHD儿童执行功能缺陷。组间比较采用MannWhitney秩和检验,并采用错误发现率(FDR)校正P值。结果:与正常对照组相比,ADHD组在持续性注意力(RVP)中平均延迟时较长,RVPA'分较低(均P<0.05);在停止信号任务(SST)中错误数得分较高,停止信号反应时间较长(均P<0.01);剑桥球袋测试(SOC)中平均启动思考时间2较长(P<0.05)。结论:本研究提示CANTAB可敏感的识别出ADHD的执行功能缺陷。Objective:To assess executive function(EF)deficit of children with attention-deficit/hyperactivity disorderby using Cambridge Neuropsychological Tests Automated Battery(CANTAB).Methods:Seventy-one children(aged 6-16 yeas)with ADHD meeting DSM-IV criteria and 28 age-,IQ-,gender-matched controls were selected.The executive function deficit in children with ADHD were evaluated with CANTAB.The Mann-whitney U non-parametric test was used to comparison between groups,and P value was corrected by False Discovery Rate(FDR).Results:Compared with controls,ADHD group had longer average delay time and lower RVPA'scores in RVP(Ps<0.05),more errors and longer stop signal reaction time in SST(Ps<0.01),and longer mean initial thinking time(2 moves)(P<0.05)in SOC.Conclusion:The study suggests that ADHD children may have widely executive function deficits,such as sustain attention,response inhibitory,and spatial planning ability,and CANTAB could sensitively identify executive function deficits of ADHD.

关 键 词：注意缺陷多动障碍 儿童 执行功能 剑桥神经心理自动化成套测试软件 

分 类 号：R749.94[医药卫生—神经病学与精神病学]