长链非编码RNA、焦亡和心肌缺血-再灌注损伤  

Long Non-coding RNA,Pyroptosis and Myocardial Ischemia/Reperfusion Injury

作　　者：何东 胡佳 陈娟[1] 韦星[1] HE Dong;HU Jia;CHEN Juan;WEI Xing(Institute of Cardiovascular Diseases,University of South China&Key Laboratory for Arteriosclerology of Hunan Province,Hunan International Scientific and Technological Cooperation Base of Arteriosclerotic Disease,Hengyang 421001,China)

机构地区：[1]南华大学心血管疾病研究所动脉硬化学湖南省重点实验室湖南省动脉硬化性疾病国际科技创新合作基地

出　　处：《生物化学与生物物理进展》2019年第12期1171-1178,共8页Progress In Biochemistry and Biophysics

摘　　要：急性心肌梗死后的再灌注是挽救缺血心肌的唯一方法,但是血流的恢复可能导致心肌缺血-再灌注损伤.长链非编码RNA(lncRNA)和焦亡都参与了心肌缺血-再灌注损伤的病理过程并发挥重要作用. lncRNA能直接或者间接作用于焦亡信号通路相关蛋白质,对包括心肌缺血-再灌注损伤在内的多种病理过程进行调控.本文就lncRNA和焦亡在心肌缺血-再灌注损伤中的作用做一综述,以进一步探索两者关系,为防治心肌缺血-再灌注损伤提供新思路.Reperfusion after acute myocardial infarction is the only way to rescue ischemic myocardium,but recovery of blood flow may lead to ischemia/reperfusion(I/R)injury.Long non-coding RNA(lnc RNA)and pyroptosis are involved in the pathological process of myocardial I/R injury and play important roles in it.Lnc RNA can directly or indirectly act on pyroptosis signaling pathway related proteins,and then regulate various pathological processes including myocardial I/R injury.In this review the roles of lnc RNA and pyroptosis in myocardial I/R are summarized to further explore the relationship between them and provide new ideas for the prevention and treatment of myocardial I/R injury.

关 键 词：长链非编码RNA 焦亡 心肌缺血-再灌注损伤 

分 类 号：R363[医药卫生—病理学]