G蛋白门控内向整流钾通道在物质成瘾中的研究进展  

Roles of G Protein-gated Inward Rectifier Potassium Channels in Substance Addiction

作　　者：茹琴 李超英 李毅 RU Qin;LI Chaoying;LI Yi(Wuhan Institute of Biomedical Sciences,Jianghan University,Wuhan 430056,China;Department of Psychiatry,Wuhan Mental Health Center,Wuhan 430012,China)

机构地区：[1]江汉大学武汉生物医学研究院,武汉430056 [2]武汉市精神卫生中心精神科,武汉430012

出　　处：《中国医学科学院学报》2020年第1期108-116,共9页Acta Academiae Medicinae Sinicae

基　　金：湖北省教育厅指导性项目(B2017273)~~

摘　　要：G蛋白门控内向整流钾(GIRK)通道在中枢神经系统中广泛分布,具有维持神经元静息电位、调节兴奋性和神经递质释放等重要作用。研究表明,成瘾行为与大脑奖赏系统中GIRK通道的表达和活性关系密切,GIRK通道可能成为成瘾治疗的潜在靶点。本文总结了近年来GIRK通道在结构、脑内分布以及物质成瘾中的研究进展,为深入理解物质成瘾的分子调控机制提供理论基础,也为临床治疗提供新的分子靶标和治疗策略。G protein-gated inward rectifier potassium(GIRK)channels are widely distributed in the central nervous system and play important roles in maintaining the resting membrane potential of neurons,adjusting neuronal excitability,and regulating the release of neurotransmitter.Studies have shown that addictive behavior is closely related to the expression and activity of the GIRK channels in the brain reward system and the GIRK channels may be a potential target for addiction treatment.This article summarizes the recent research advances in GIRK channels in terms of structure,intracranial tissue distribution,and especially substance addiction.

关 键 词：G蛋白门控内向整流钾通道 物质成瘾 

分 类 号：R749.6[医药卫生—神经病学与精神病学]