Activation of Uterine Smad3 Pathway Is Crucial for Embryo Implantation  

作　　者：Juan LI Xi-yuan DONG Pei-wen YANG Shu-lin YANG Dan HU Han-wang ZHANG Cong SUI 

机构地区：[1]Reproductive Medicine Center,Tongji Hospital Tongji Medicine College,Huazhong University of Science and Technology,Wuhan 430030,China [2]Department of Gynecology,Women's Hospital,School of Medicine,Zhejiang University,Hangzhou 310000,China

出　　处：《Current Medical Science》2019年第6期997-1002,共6页当代医学科学（英文）

基　　金：the National Natural Science Foundation of China(No.81701450).

摘　　要：Embryo implantation is a complicated physiological process tightly regulated by multiple biological molecules including growth factors.Transforming growth factor-betas(TGF-βs)and their most specific signal transduction factors,Smads,are expressed in the endometrium during the window of implantation.Recent researches indicated that Smad dependent TGF-β signaling may play an important role in the process of embryo implantation.In this study,we measured the expression of TGF-β1,TGF-β receptor type I(TpRI),Smad3 and p-Smad3 in the endometrium of mice and observed their elevation on day 4,5 and 6 of pseudopregnancy.Then we administrated a specific Smad3 inhibitor(Sis3)into the uterine cavity of mice on day 3 of pregnancy.The results showed a reduction in insulin-like growth factor-1(IGFBP-1)expression and the decreased number of implanted embryo after the administration.In addition,Sis3 was found to reduce the IGFBP-1 secretion in decidualized endometrial stromal cells.Taken all together,our findings demonstrated that TGF-β/Smad3 signaling is involved in the process of embryo implantation.

关 键 词：transforming growth factor-betas(TGF-βs) SMAD3 endometrial receptivity DECIDUALIZATION embryo implantation 

分 类 号：R71[医药卫生—妇产科学]