人参皂苷Rd注射液联合阿替普酶对脑卒中患者血液流变学、炎性反应和血管内皮功能的影响  

Effects of ginsenoside Rd injection combined with alteplase on hemorheology, inflammation reaction and vascular endothelial function in patients with acute ischemic cerebral stroke

作　　者：刘运平[1] 段海丽[1] 吕学海[1] 叶秋桠 郭志娟 胡芳 王慧娟[2] 曹妍[2] LIU Yunping;DUAN Haili;LV Xuehai(Department of Rehabilitation Medicine,Central Hospital of Handan City,Hebei,Handan 056000,China)

机构地区：[1]河北省邯郸市中心医院康复医学科,056000 [2]河北省邯郸市中心医院神经内二科,056000

出　　处：《河北医药》2020年第3期423-426,共4页Hebei Medical Journal

摘　　要：目的研究人参皂苷Rd注射液联合注射用阿替普酶对急性缺血性脑卒中患者血液流变学、炎性反应和血管内皮功能的影响。方法选取2016年10月至2018年10月住院治疗的急性缺血性脑卒中患者180例,随机分为对照组和治疗组,每组90例。对照组在常规治疗基础上给予注射用阿替普酶治疗,治疗组在对照组基础上联合应用人参皂苷Rd注射液治疗,疗程2周。观察2组治疗前后血脂[总胆固醇(TC)、三酰甘油(TG)]、血液流变学指标(血浆黏度、红细胞压积、血小板黏附率)、血清炎性因子[C-反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)]、血管内皮功能指标[内皮素-1(ET-1)、一氧化氮(NO)]及外周血单核细胞(PBMC)NF-κB表达。结果2组治疗前TC、TG、血浆黏度、红细胞压积、血小板黏附率、血清CRP、TNF-α、ET-1、NO及PBMC NF-κB表达比较差异无统计学意义(P>0.05);与治疗前比较,2组治疗后TC、TG、血浆黏度、红细胞压积、血小板黏附率、血清CRP、TNF-α、ET-1及PBMC NF-κB表达均显著降低,NO均显著增加,差异有统计学意义(P<0.05),且治疗组治疗后上述指标与对照组比较,差异有统计学意义(P<0.05)。结论人参皂苷Rd注射液联合注射用阿替普酶治疗急性缺血性脑卒中患者,可以显著降低血脂,抑制炎性反应,并改善血液流变学和血管内皮功能。Objective To investigate the effects of ginsenoside Rd injection combined with alteplase on hemorheology,inflammation reaction and vascular endothelial function in patients with acute ischemic cerebral stroke.Methods A total of 180 patients with acute ischemic cerebral stroke who were admitted and treated in our hospital from October 2012 to Jully 2014 were enrolled in the study,who were randomly divided into treatment group(n=90)and control group(n=90).The patients in control group were treated by intravenous thrombolysis with alteplase on the basis of the standard treatment,and the patients in treatment group,on the basis of control group,were treated by ginsenoside Rd injection,with a treatment course of two weeks for both groups.After treatment,the levels of TC,TG,plasma viscosity,hematocrit,platelet adhesion rate,and serum levels of CRP,TNF-α,ET-1,NO and the expression levels of NF-κB in PBMC were observed and compared between the two groups.Results Before treating,there were no significant differences in the levels of TC,TG,plasma viscosity,hematocrit,platelet adhesion rate,and serum levels of CRP,TNF-α,ET-1,NO as well as the expression levels of NF-κB in PBMC between two groups(P>0.05).As compared with those before treatment,the levels of TC,TG,plasma viscosity,hematocrit,platelet adhesion rate,serum levels of CRP,TNF-α,ET-1 and the expression levels of NF-κB in PBMC were significantly decreased in both groups,however,the serum levels of NO were significantly increased in both groups(P<0.05).Moreover there were significant differences in the above indexes between the two groups(P<0.05).Conclusion Ginsenoside Rd injection combined with alteplase in treatment of acute ischemic cerebral stroke can significantly decrease blood lipids,inhibit inflammatory reaction,improve hemorheology and vascular endothelial function of patients.

关 键 词：人参皂苷Rd注射液 注射用阿替普酶 急性缺血性脑卒中 血液流变学 炎性反应 血管内皮功能 

分 类 号：R743.33[医药卫生—神经病学与精神病学]